LSA — also known as ergine — is a psychedelic compound with a long history of use. However, for various reasons, it is not a common psychedelic to use.
Based on the family of compounds it belongs to, it shares some similarities with LSD. But there are important differences between the two drugs as well.
This guide will explore all aspects of LSA, including its chemistry, pharmacology, history, effects, and legal status.
LSA is a natural psychedelic compound belonging to the lysergamide class of alkaloids. Lysergamides are amides of lysergic acid.
The chemical structure of LSA is made up of a core structure of lysergic acid. It is structurally similar to LSD.
LSA, like classic psychedelics such as LSD, causes psychedelic effects by binding to serotonin 5-HT2A receptors in the brain.
However, researchers note that LSD has a stronger affinity for these receptors compared to LSA. This is most likely why the psychedelic effects of LSD are stronger than those of LSA.
The cultural use of LSA extends back to the ancient Maya civilization (250 BCE-900 AD).
What Is LSA? A Brief History