While “Monday blues” is another common term used to refer to this so-called MDMA hangover, many people don’t actually experience these effects the next day (i.e. Monday), but the day after.
The Tuesday blues, otherwise known as “suicide Tuesdays”, refer to the MDMA comedown. As the saying goes, “what goes up must come down.”
MDMA is known to produce (sometimes intense) states of joy, elation, bliss, empathy, emotional openness, and love. This experience lasts for several hours but can be extended if you redose.
MDMA causes its desired effects by creating an increase in the levels of the neurotransmitters serotonin, norepinephrine, and dopamine.
Serotonin plays a crucial role in the regulation of mood, sleep, pain, appetite, and other behaviors. The surge of serotonin is likely what causes the mood-elevating effects of MDMA.
Even though the classic effects of the drug have faded, you might still feel a sense of well-being, affection towards others, and relaxation.
The reason for the delayed comedown is that MDMA increases serotonin levels for a long period of time.
If you redose, you’re basically “stacking half-lives,” says James Giordano, professor of neurology and biochemistry at Georgetown University Medical Center.