✓ Last verified: October 5, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Known For: Multi-specialty psychiatric practice in the Financial District offering ketamine injections and TMS alongside ADHD and mood disorder treatment, with a focus on executive and professional mental health.
Accepts most major insurance for psychiatric services; TMS coverage varies
KAP Available
Yes – integrated with psychiatric care
Clinical Lead
Board-certified psychiatrists
HealingMaps Take: Trifecta Health is a strong option for patients who need both ketamine therapy and broader psychiatric support, especially for ADHD and mood disorders. Their multi-treatment approach (ketamine injections, TMS, and psychotherapy) gives clinicians flexibility to tailor protocols. Insurance acceptance for many services makes this more accessible than cash-only clinics. Well-suited for busy professionals in the FiDi area.
Market Position: Trifecta Health is a multi-specialty psychiatric practice in the Manhattan metro offering ketamine injections, TMS, and psychotherapy. The practice does not offer Spravato (esketamine).
Is Trifecta Health Right for You?
✓ Choose Trifecta Health if:
You want ketamine treatment inside a broader psychiatric practice (ADHD, mood disorders, TMS)
You want supervised IV ketamine with real-time medical monitoring
You’re seeking ketamine-assisted psychotherapy (KAP) with a licensed therapist alongside dosing
You’re treating co-occurring depression and PTSD
✗ Look elsewhere if:
You’re seeking Spravato (esketamine), which Trifecta Health does not offer
You’re seeking ketamine for chronic pain (this clinic focuses on mental health)
Trifecta Health Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
Estimated per session
$525–$900
Range: $450–$1,500/session
Estimated total program
$3,150–$5,400
Range: $2,700–$9,000/6-session series
Your estimate vs. national patient-reported medianBased on national tracking, adjusted for Manhattan, NY market
Select a treatment type to see pricing context.
Get matched to verified clinics
A HealingMaps specialist will follow up within one business day with providers that match your estimate, protocol, and insurance situation.
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A HealingMaps specialist will reach out within one business day with clinic matches based on your estimate. In the meantime, review the verified providers below.
Ketamine Protocols Compared — What’s Offered at Trifecta Health
Industry pricing reference. Trifecta Health has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.
Protocol
Typical Industry Cost
Offered Here
IV Ketamine
$350–$650/session
✓ Yes
Spravato (esketamine)
$0–$250 copay (insured)
—
IM Ketamine
$250–$400/injection
—
KAP (with therapist)
$400–$1,200/session
✓ Yes
At-home troches
$150–$300/month
—
What to Expect at Your First Trifecta Health Appointment
Initial intake call — Medical history review and clinical eligibility check. Call (212) 233-2830 or visit trifectahealthnyc.com to schedule.
Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Trifecta Health clinical team.
First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at 115 Broadway, Suite 1300, Manhattan, NY 10006. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.
What to Ask on Your Trifecta Health Consult Call
How long has the Trifecta Health clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
Do you provide superbills or HSA/FSA-eligible billing for out-of-pocket treatment?
Is the therapist who guides KAP sessions independently licensed, and how long are integration sessions after the dosing portion?
What does Trifecta Health recommend for patients who don’t respond to the standard 6-session acute series?
Patient Questions about Trifecta Health
This 5-question summary is matched to the protocols and conditions Trifecta Health treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
What ketamine protocols does Trifecta Health offer?
Trifecta Health offers ketamine injections for treatment-resistant depression, alongside TMS, psychopharmacology, and psychotherapy. The practice does not offer Spravato (esketamine). Confirm current protocols during your consult.
Does Trifecta Health offer Spravato (esketamine)?
No. Trifecta Health does not offer Spravato (esketamine); its ketamine treatment is delivered as ketamine injections, with TMS and medication management also available. Patients seeking Spravato specifically will need a REMS-certified Spravato provider instead.
Is Trifecta Health suited for treatment-resistant depression?
Yes — Dr. Edward Fruitman offers ketamine injections for treatment-resistant depression, with TMS as an additional interventional option. TRD is typically defined as two or more prior antidepressant trials without sufficient response. The practice does not offer Spravato, so Spravato’s insurance-covered TRD pathway is not available here.
Does Trifecta Health treat PTSD?
Yes — Trifecta Health treats PTSD. Ketamine-class treatments can be used for trauma. Ketamine for trauma differs from depression treatment: dosing is often lower per session, and pairing the protocol with trauma-focused therapy between sessions is common. A reasonable consult question: whether PTSD patients here typically use ketamine alone or alongside an outside therapist.
Can Trifecta Health help with anxiety disorders?
Yes — Trifecta Health treats anxiety, including generalized anxiety, social anxiety, and panic disorder. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which of their protocols they typically recommend for anxiety-primary patients.
The Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
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