Trifecta Health – Manhattan, New York Ketamine Clinics, Spravato Clinics

✓ Last verified: January 24, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff

Known For: Multi-specialty psychiatric practice in the Financial District offering ketamine infusions, Spravato, and TMS alongside ADHD and mood disorder treatment, with a focus on executive and professional mental health.

HealingMaps Take: Trifecta Health is a strong option for patients who need both ketamine therapy and broader psychiatric support, especially for ADHD and mood disorders. Their multi-treatment approach (ketamine, TMS, Spravato) gives clinicians flexibility to tailor protocols. Insurance acceptance for many services makes this more accessible than cash-only clinics. Well-suited for busy professionals in the FiDi area.

Market Position: Trifecta Health is a Spravato-certified clinic in the Manhattan metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.

Trifecta Health Ketamine Cost Calculator

Ketamine Protocols Compared — What’s Offered at Trifecta Health

Industry pricing reference. Trifecta Health has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.

What to Expect at Your First Trifecta Health Appointment

1. Initial intake call — Insurance verification, prior authorization workflow (Spravato requires documentation of failure on at least two antidepressant trials), and clinical eligibility check. Call (212) 233-2830 or visit trifectahealthnyc.com to schedule.
2. Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Trifecta Health clinical team.
3. First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at 115 Broadway, Suite 1300, Manhattan, NY 10006. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
4. Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.

What to Ask on Your Trifecta Health Consult Call

• How long has the Trifecta Health clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
• Walk me through Trifecta Health’s Spravato prior authorization process versus your IV ketamine cash-pay or superbill workflow — which is the better fit for my insurance situation?
• Which New York commercial insurers (Aetna, UnitedHealthcare, Empire BCBS, Oxford, Healthfirst) have you successfully obtained Spravato prior authorization through?
• Is the therapist who guides KAP sessions independently licensed, and how long are integration sessions after the dosing portion?
• What does Trifecta Health recommend for patients who don’t respond to the standard 6-session acute series?

Patient Questions about Trifecta Health

This 5-question summary is matched to the protocols and conditions Trifecta Health treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.

What ketamine protocols does Trifecta Health offer?

Trifecta Health offers Spravato and IV ketamine — a 2-protocol practice. Patients can switch between or combine modalities without changing providers. Confirm specific dosing schedules and which protocols are recommended for your condition during your consult.

Does Trifecta Health offer Spravato (esketamine)?

Yes — Trifecta Health offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.

Is Trifecta Health suited for treatment-resistant depression?

Trifecta Health treats depression via Spravato (FDA-approved for TRD), and IV ketamine (off-label, evidence-based). The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.

Does Trifecta Health treat PTSD?

Yes — Trifecta Health treats PTSD. Both Spravato and IV ketamine can be used for trauma. Ketamine for trauma differs from depression treatment: dosing is often lower per session, and pairing the protocol with trauma-focused therapy between sessions is common. A reasonable consult question: whether PTSD patients here typically use ketamine alone or alongside an outside therapist.

Can Trifecta Health help with anxiety disorders?

Yes — Trifecta Health treats anxiety, including generalized anxiety, social anxiety, and panic disorder. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which of their protocols they typically recommend for anxiety-primary patients.

View all REMS-certified Spravato clinics in New York and across the United States.

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