✓ Last verified: January 31, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff

Known For: Yale New Haven Psychiatric Hospital houses one of the most historically significant ketamine therapy programs in the world. Yale researchers were the first to discover in the late 1990s that ketamine provided rapid relief for treatment-resistant depression, and their Interventional Psychiatric Program now treats 20–30 patients weekly. The hospital offers both IV ketamine infusions and Spravato® (esketamine) nasal spray, backed by decades of clinical research and the full resources of a major academic medical center.
| Google Reviews | ⭐ Academic Medical Center – Yale-affiliated |
| Location | New Haven, Connecticut |
| Address | 184 Liberty Street, New Haven, CT 06519 |
| Phone | (203) 688-9704 |
| Website | ynhh.org |
| Treatments | IV Ketamine Infusions, Spravato® (Esketamine) Nasal Spray, TMS, ECT |
| Conditions Treated | Treatment-Resistant Depression, MDD with Suicidal Ideation, PTSD, Anxiety, Bipolar Depression |
| Cost | Contact for pricing – Hospital-based program |
| Insurance | Medicare, Medicaid, and most commercial insurance accepted for Spravato® and ketamine |
| KAP Available | Clinical ketamine protocol – Psychiatric oversight during sessions |
| Clinical Lead | Yale Department of Psychiatry – Dr. John Krystal, Department Chair |
HealingMaps Take: If there’s one ketamine program with unmatched research credentials, it’s Yale’s. The Interventional Psychiatric Program at Yale New Haven is where ketamine’s antidepressant properties were first clinically demonstrated, and the program continues to operate at the forefront of the field. This is a hospital-based setting, so expect a more clinical atmosphere than a private boutique clinic — but the tradeoff is access to a full psychiatric team, insurance coverage (including Medicare and Medicaid), and the reassurance of being treated by the institution that literally pioneered this therapy. An excellent choice for patients who prioritize evidence-based care and insurance accessibility.
Market Position: Yale New Haven Psychiatric Hospital is a Spravato-certified clinic in the Haven metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.
Industry pricing reference. Yale New Haven Psychiatric Hospital has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.
| Protocol | Typical Industry Cost | Offered Here |
|---|---|---|
| IV Ketamine | $350–$650/session | ✓ Yes |
| Spravato (esketamine) | $0–$250 copay (insured) | ✓ Yes |
| IM Ketamine | $250–$400/injection | — |
| KAP (with therapist) | $400–$1,200/session | — |
| At-home troches | $150–$300/month | — |
Sources: CDC PLACES 2023 (Connecticut, state-level prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.
Behind this data: HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,473 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.
For patients whose HSA or FSA funds are insufficient, third-party medical financing programs like CareCredit are accepted at a growing share of ketamine clinics — typically offering 6 to 24-month deferred-interest plans on the full acute-series cost of $2,100–$3,000. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.
This 5-question summary is matched to the protocols and conditions Yale New Haven Psychiatric Hospital treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
Yale New Haven Psychiatric Hospital offers Spravato and IV ketamine — a 2-protocol practice. Patients can switch between or combine modalities without changing providers. Confirm specific dosing schedules and which protocols are recommended for your condition during your consult.
Yes — Yale New Haven Psychiatric Hospital offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.
Yale New Haven Psychiatric Hospital treats depression via Spravato (FDA-approved for TRD), and IV ketamine (off-label, evidence-based). The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.
Yes — Yale New Haven Psychiatric Hospital treats PTSD. Both Spravato and IV ketamine can be used for trauma. Ketamine for trauma differs from depression treatment: dosing is often lower per session, and pairing the protocol with trauma-focused therapy between sessions is common. A reasonable consult question: whether PTSD patients here typically use ketamine alone or alongside an outside therapist.
Yes — Yale New Haven Psychiatric Hospital treats anxiety, including generalized anxiety, social anxiety, and panic disorder. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which of their protocols they typically recommend for anxiety-primary patients.
This clinic offers TMS therapy as a third FDA-cleared treatment option (alongside ketamine and Spravato) for patients with treatment-resistant depression. Patients drive themselves to and from sessions, return to work the same day, and need no chaperone or recovery period. Read our complete guide to TMS therapy for FDA-cleared conditions, device differences, insurance coverage by carrier, and what to expect at your first appointment. Browse verified TMS clinics in our directory.
View all REMS-certified Spravato clinics in Connecticut and across the United States.
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