✓ Last verified: February 1, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Known For: Greenbrook TMS NeuroHealth Centers in Irvine is part of one of the largest national networks dedicated to TMS therapy and Spravato (esketamine) nasal spray. The Irvine location serves central Orange County with FDA-approved treatments for treatment-resistant depression, combining the accessibility of a national network with personalized local care.
TMS (Transcranial Magnetic Stimulation), Spravato (Esketamine) Nasal Spray
Conditions Treated
Treatment-Resistant Depression, Major Depressive Disorder
Cost
Contact clinic for pricing; Spravato and TMS often covered by insurance
Insurance
Most major insurance plans accepted
KAP Available?
No — Spravato nasal spray protocol (not IV ketamine)
Clinical Lead
Greenbrook TMS clinical team
💡 No clinic-specific pricing posted? See our ketamine therapy cost guide for typical pricing ranges by treatment type and insurance pathways.
HealingMaps Take: Greenbrook’s Irvine center provides a convenient option for Orange County residents seeking FDA-cleared alternatives to traditional antidepressants. Their combination of TMS and Spravato (esketamine) means patients can access two different evidence-based approaches through one provider. The national network’s insurance infrastructure simplifies coverage, making these treatments more financially accessible than many standalone ketamine clinics. A solid choice for patients wanting a well-established, insurance-friendly path to treatment.
Market Position: Greenbrook TMS is a verified ketamine provider in the Irvine metro on HealingMaps — one of 1,473 clinics we have mapped and tracked across 3,142 U.S. counties.
Is Greenbrook TMS Right for You?
✓ Choose Greenbrook TMS if:
You want a multi-protocol practice (Spravato + IV ketamine) where you can switch between modalities without changing providers
You want commercial-insurance-covered Spravato (esketamine) for treatment-resistant depression
You want comprehensive interventional psychiatry combining ketamine with TMS (transcranial magnetic stimulation)
You're treating chronic pain (CRPS, fibromyalgia, neuropathy) and want IV ketamine protocols
✗ Look elsewhere if:
You want ketamine-assisted psychotherapy (KAP) with integrated talk therapy (this clinic uses the medical model)
⚠ FDA-cleared indications for TMS therapy: treatment-resistant major depressive disorder (MDD), obsessive-compulsive disorder (OCD, Deep TMS only), anxious depression, short-term smoking cessation, and adolescent MDD (ages 15–21). Use of TMS for other conditions including PTSD, bipolar depression, fibromyalgia, and other indications is off-label — not currently FDA-cleared for those specific indications. Discuss your condition with the clinic to understand insurance coverage and clinical evidence.
Greenbrook TMS Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
Estimated per session
$473–$810
Range: $405–$1,350/session
Estimated total program
$2,835–$4,860
Range: $2,430–$8,100/6-session series
Your estimate vs. national patient-reported medianBased on national tracking, adjusted for Orange County, CA market
Select a treatment type to see pricing context.
Get matched to verified clinics
A HealingMaps specialist will follow up within one business day with providers that match your estimate, protocol, and insurance situation.
✓ Request received.
A HealingMaps specialist will reach out within one business day with clinic matches based on your estimate. In the meantime, review the verified providers below.
Ketamine Protocols Compared — What’s Offered at Greenbrook TMS
Industry pricing reference. Greenbrook TMS has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.
Protocol
Typical Industry Cost
Offered Here
IV Ketamine Infusion
$350–$650/session
✓
Spravato (esketamine)
$0–$250 copay (insured)
✓
TMS (transcranial magnetic stimulation)
$200–$300/session, often insurance-covered
✓
IM Ketamine
$250–$400/injection
—
KAP (with integrated talk therapy)
$400–$1,200/session
—
At-home oral troches
$150–$300/month
—
What to Expect at Your First Greenbrook TMS Appointment
Initial intake call — Medical history review and clinical eligibility check. Call (855) 940-4867 to schedule.
Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Greenbrook TMS clinical team.
First treatment session — supervised ketamine therapy session in a private treatment room, lasting approximately 60–90 minutes. Sessions are held at 17782 Cowan Street, Suite D, Irvine, CA 92614. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your ketamine session.
What to Ask on Your Greenbrook TMS Consult Call
How long has the Greenbrook TMS clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
What’s a typical 6-session total cost at Greenbrook TMS, and do you offer payment plans, HSA/FSA-eligible billing, or sliding-scale pricing?
California’s psychedelic-therapy regulatory landscape is evolving — do you stay current with state Department of Public Health and Medical Board guidance on ketamine prescribing?
What does Greenbrook TMS recommend for patients who don’t respond to the standard 6-session acute series?
Patient Questions about Greenbrook TMS
This 2-question summary is matched to the protocols and conditions Greenbrook TMS treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
Does Greenbrook TMS offer Spravato (esketamine)?
Yes — Greenbrook TMS offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.
Is Greenbrook TMS suited for treatment-resistant depression?
Greenbrook TMS treats depression via Spravato (FDA-cleared for TRD). The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.
This clinic provides three FDA-cleared interventional psychiatry options: ketamine therapy, Spravato (esketamine), and TMS therapy. TMS sessions take 19 to 37 minutes (or 3 minutes for the iTBS protocol), with no anesthesia, sedation, or controlled-substance handling. This clinic uses BrainsWay Deep TMS, the only TMS device with standalone FDA clearance for OCD via the H7 coil. Read our complete guide to TMS therapy for FDA-cleared conditions, device differences, insurance coverage by carrier, and what to expect at your first appointment. Browse verified TMS clinics in our directory.
The Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
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