✓ Last verified: February 11, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Known For: Greenbrook TMS San Luis Obispo brings the national Greenbrook network’s insurance-covered Spravato (esketamine) and TMS therapy to California’s Central Coast. Located on South Higuera Street, this center provides FDA-approved treatments for treatment-resistant depression and MDD with suicidal ideation. As part of Greenbrook’s standardized clinical network, patients benefit from established protocols and quality standards while accessing care locally rather than traveling to Los Angeles or the Bay Area.
Google Reviews
⭐ 4.5 (National Network)
Location
San Luis Obispo, California
Address
3220 S Higuera St, Suite 306, San Luis Obispo, CA 93401
Treatment-Resistant Depression, MDD with Suicidal Ideation
Cost
Covered by most major insurance plans
Insurance
Most major insurance accepted for both Spravato and TMS
KAP Available
No — Spravato administered under medical supervision (not KAP)
Clinical Lead
Greenbrook TMS Clinical Team
HealingMaps Take: For Central Coast residents, Greenbrook SLO provides an important insurance-covered pathway to ketamine-based treatment. Spravato’s FDA approval means it has undergone rigorous clinical trials, and insurance coverage removes the major financial barrier that makes IV ketamine inaccessible for many patients. While Spravato is a nasal spray rather than an IV infusion and doesn’t include psychotherapy integration, it’s a proven option for patients with treatment-resistant depression. Combined with TMS therapy availability, this location gives SLO-area patients two advanced treatment modalities under one roof.
Market Position: Greenbrook TMS is a Spravato-certified clinic in the Obispo metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.
Is Greenbrook TMS Right for You?
✓ Choose Greenbrook TMS if:
You have commercial insurance and a documented treatment-resistant depression diagnosis (Spravato pathway)
✗ Look elsewhere if:
You’re seeking cash-pay IV ketamine instead of insurance-billed Spravato
You want ketamine-assisted psychotherapy (KAP) with integrated talk therapy
You need same-week appointments — Spravato prior authorization typically takes 1–3 weeks
⚠ FDA-cleared indications for TMS therapy: treatment-resistant major depressive disorder (MDD), obsessive-compulsive disorder (OCD, Deep TMS only), anxious depression, short-term smoking cessation, and adolescent MDD (ages 15–21). Use of TMS for other conditions including PTSD, bipolar depression, fibromyalgia, and other indications is off-label — not currently FDA-cleared for those specific indications. Discuss your condition with the clinic to understand insurance coverage and clinical evidence.
Greenbrook TMS Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
Estimated per session
$525–$900
Range: $450–$1,500/session
Estimated total program
$3,150–$5,400
Range: $2,700–$9,000/6-session series
Your estimate vs. national patient-reported medianBased on national tracking, adjusted for Los Angeles, CA market
Select a treatment type to see pricing context.
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A HealingMaps specialist will follow up within one business day with providers that match your estimate, protocol, and insurance situation.
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Ketamine Protocols Compared — What’s Offered at Greenbrook TMS
Industry pricing reference. Greenbrook TMS’s posted price: Covered by most major insurance plans. Contact the clinic for any package or sliding-scale options. The calculator above shows metro-level cost estimates across protocols.
Protocol
Typical Industry Cost
Offered Here
IV Ketamine
$350–$650/session
—
Spravato (esketamine)
$0–$250 copay (insured)
✓ Yes
IM Ketamine
$250–$400/injection
—
KAP (with therapist)
$400–$1,200/session
—
At-home troches
$150–$300/month
—
What to Expect at Your First Greenbrook TMS Appointment
Initial intake call — Insurance verification, prior authorization workflow (Spravato requires documentation of failure on at least two antidepressant trials), and clinical eligibility check. Call (855) 940-4867 or visit greenbrooktms.com to schedule. Greenbrook TMS’s posted pricing: Covered by most major insurance plans.
Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Greenbrook TMS clinical team.
First treatment session — supervised Spravato (intranasal esketamine) in a private treatment room, lasting approximately 90 minutes (40-minute session + 60 minutes monitoring). Sessions are held at 3220 S Higuera St, Suite 306, San Luis Obispo, CA 93401. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your Spravato session.
What to Ask on Your Greenbrook TMS Consult Call
How long has the Greenbrook TMS clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
How long does Greenbrook TMS’s Spravato prior authorization typically take with my specific insurance plan, and what happens if it’s denied?
California’s psychedelic-therapy regulatory landscape is evolving — do you stay current with state Department of Public Health and Medical Board guidance on ketamine prescribing?
What does Greenbrook TMS recommend for patients who don’t respond to the standard 6-session acute series?
Patient Questions about Greenbrook TMS
This 2-question summary is matched to the protocols and conditions Greenbrook TMS treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
Does Greenbrook TMS offer Spravato (esketamine)?
Yes — Greenbrook TMS offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.
Is Greenbrook TMS suited for treatment-resistant depression?
Greenbrook TMS treats depression via Spravato (FDA-cleared for TRD). The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.
TMS therapy is also available at this clinic, alongside ketamine and Spravato. Unlike cash-pay ketamine, TMS is covered by most major insurance plans for treatment-resistant depression. TMS is FDA-cleared for treatment-resistant depression (since 2008), OCD via Deep TMS, anxious depression, and adolescent MDD ages 15–21. This clinic uses BrainsWay Deep TMS, the only TMS device with standalone FDA clearance for OCD via the H7 coil. Read our complete guide to TMS therapy for FDA-cleared conditions, device differences, insurance coverage by carrier, and what to expect at your first appointment. Browse verified TMS clinics in our directory.
The Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
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