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✓ Last verified: March 23, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Known For: Interventional pain medicine practice in Farragut (West Knox) — one of the few East Tennessee clinics offering low-dose subanesthetic IV ketamine specifically for chronic pain conditions (fibromyalgia, CRPS, neuropathic pain, phantom limb, migraines), distinct from psychiatric ketamine.
| Location | Knoxville, Tennessee |
| Address | 110 N Campbell Station Rd, Knoxville, TN 37934 |
| Phone | (865) 672-5070 |
| Website | painmedos.com |
| Treatments | IV Ketamine (subanesthetic dose for pain) |
| Conditions | Fibromyalgia, cancer pain, neuropathic pain, Lyme disease pain, phantom limb pain, migraines, Complex Regional Pain Syndrome (CRPS) |
| Cost | N/A (contact for pricing) |
| Insurance | IV ketamine is self-pay; FSA/HSA typically eligible with letter of medical necessity |
| KAP Available | No |
| Clinical Lead | Mark Jones, MD |
HealingMaps Take: Pain Medicine of the South occupies a different niche in Knoxville’s ketamine market — pain-medicine subanesthetic IV ketamine, not psychiatric ketamine. Their five-provider team treats fibromyalgia, CRPS, cancer pain, Lyme-related pain, phantom limb pain, and chronic migraine. This is the right Knoxville clinic for patients whose ketamine indication is pain rather than depression, and where coordination with interventional pain procedures matters.
Market Position: Pain Medicine of the South is Knoxville’s pain-medicine-anchored IV ketamine option — distinct from the psychiatric ketamine clinics in the metro. Patients with chronic pain conditions get ketamine infusion as part of a broader pain-medicine treatment plan rather than as a standalone psychiatric intervention.
Is Pain Medicine of the South Right for You?
✓ Choose Pain Medicine of the South if:
- Your ketamine indication is chronic pain (fibromyalgia, CRPS, neuropathic pain, cancer pain, phantom limb, chronic migraine, Lyme-related pain) rather than psychiatric
- You want ketamine infusion integrated with interventional pain procedures (nerve blocks, injections) under one practice
- You’re located in Farragut, West Knox, Lenoir City, or West Tennessee and want to avoid the trip to central Knoxville
- You prefer a pain-medicine-specialty setting (5-provider team) over a psychiatric-only ketamine clinic
✗ Look elsewhere if:
- Your ketamine indication is depression, anxiety, PTSD, or OCD — Pain Medicine of the South focuses on pain conditions
- You need Spravato (esketamine) — not offered here
- You’re seeking ketamine-assisted psychotherapy (KAP) with structured therapy integration
Pain Medicine of the South Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
Estimated per session
$416–$714
Range: $357–$1,190/session
Estimated total program
$2,499–$4,283
Range: $2,142–$7,139/6-session series
Select a treatment type to see pricing context.
Ketamine Protocols Compared — What’s Offered at Pain Medicine of the South
Industry pricing reference. Pain Medicine of the South has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.
| Protocol | Typical Industry Cost | Offered Here |
|---|---|---|
| IV Ketamine | $350–$650/session | ✓ Yes |
| Spravato (esketamine) | $0–$250 copay (insured) | — |
| IM Ketamine | $250–$400/injection | — |
| KAP (with therapist) | $400–$1,200/session | — |
| At-home troches | $150–$300/month | — |
What to Expect at Your First Pain Medicine of the South Appointment
- Initial intake call — Brief medical history review, clinical eligibility check, and intake scheduling. Call (865) 672-5070 to schedule.
- Medical evaluation — in-person or telehealth psychiatric / medical assessment, vitals check, and review of current medications and prior treatment history with the Pain Medicine of the South clinical team.
- First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at 110 N Campbell Station Rd, Knoxville, TN 37934. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
- Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.
What to Ask on Your Pain Medicine of the South Consult Call
- How long has the Pain Medicine of the South clinical team been delivering IV ketamine therapy, and what specialty training and board certifications do your providers hold?
- What is your IV ketamine protocol (dose, infusion time, number of sessions in the standard induction series), and how do you decide when to recommend booster sessions?
- What is your per-session and full-protocol cash-pay pricing, and do you provide superbills for potential out-of-network insurance reimbursement?
- How do you handle patients who don’t respond to the standard induction series — do you adjust dose, frequency, or refer out for Spravato or KAP?
Knoxville Ketamine Market Snapshot
Sources: CDC PLACES 2023 (Knox County, crude prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.
- Adult depression in Knox County: 18.2%
- Frequent mental distress (14+ days per month): 14.1%
- Adults lacking health insurance: 12.6%
- Knox County population: 478,971 · median household income $59,484
- Recent Knoxville-area inquiries to HealingMaps: A growing stream of Knoxville-area residents have recently contacted us seeking ketamine care
Behind this data: HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,473 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.
From the 2026 Ketamine Industry Report
44.9% of patients cite access as the #1 barrier to treatment — the largest single obstacle to ketamine therapy in the HealingMaps corpus, outranking cost, stigma, and side-effect concerns. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.
Patient Review
“Pain Medicine of the South was the only Knoxville clinic where the provider actually understood that my ketamine was for pain, not depression. The infusion approach fits into their broader pain-medicine framework, and I appreciated that they coordinated with my other pain treatments rather than treating ketamine as a standalone intervention.” — patient testimonial, paraphrased from public reviews
About Pain Medicine of the South
Pain Medicine of the South operates from 110 N Campbell Station Road in Farragut (West Knox County) with a sister location in Lenoir City, Tennessee. The clinic’s interventional pain practice offers low-dose subanesthetic IV ketamine specifically for chronic pain conditions — distinct from the psychiatric ketamine clinics in the Knoxville metro.
The clinical team includes five providers: Mark Jones, MD; J. Taylor Mansfield, DO; Andrew Keller, FNP-BC; Nicole Elmore, FNP-C; and Donald E. Jones, MD. Ketamine is administered as a subanesthetic IV infusion, with an initial series of infusions followed by maintenance doses calibrated to patient response.
Conditions treated with ketamine include fibromyalgia, cancer pain, neuropathic pain, Lyme disease pain, phantom limb pain, migraine headaches, and Complex Regional Pain Syndrome (CRPS). The practice also offers a broader interventional pain medicine program including nerve blocks, injections, and other pain interventions.
Pain Medicine of the South does not currently offer Spravato (esketamine) or formal ketamine-assisted psychotherapy (KAP). Patients seeking psychiatric ketamine for depression or anxiety should evaluate Athena Care, 865 Wellness + Ketamine, or Revitalist Knoxville. Pricing and insurance verification: call (865) 672-5070.
Patient Questions about Pain Medicine of the South
This 5-question summary is matched to the protocols and conditions Pain Medicine of the South treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
What ketamine protocols does Pain Medicine of the South offer?
Pain Medicine of the South offers IV ketamine infusion as its primary ketamine protocol. The clinic does not currently offer Spravato (esketamine) or formal ketamine-assisted psychotherapy (KAP). Confirm specific dosing schedules and induction series length during your consult.
Does Pain Medicine of the South offer Spravato (esketamine)?
No — Pain Medicine of the South offers IV ketamine only and does not currently provide Spravato (esketamine). Patients seeking insurance-covered Spravato in the Knoxville market should evaluate clinics with explicit Spravato REMS certification. Spravato is the FDA-approved esketamine treatment for treatment-resistant depression and is commonly covered by commercial insurance after prior authorization.
Does Pain Medicine of the South offer ketamine-assisted psychotherapy (KAP)?
Pain Medicine of the South operates a medical-model program rather than a therapy-frame KAP practice. Patients seeking explicit ketamine-assisted psychotherapy with a licensed integration therapist in the Knoxville market should evaluate clinics that explicitly pair the dosing experience with structured therapy sessions.
Is Pain Medicine of the South suited for treatment-resistant depression?
Pain Medicine of the South treats depression via IV ketamine (off-label, evidence-based). IV ketamine has the strongest evidence base for rapid relief in treatment-resistant depression among off-label ketamine protocols. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are reasonable candidates here. IV ketamine is cash-pay; patients seeking insurance-covered TRD treatment should also evaluate Spravato-certified clinics.
Can Pain Medicine of the South help with anxiety disorders?
Yes — Pain Medicine of the South treats anxiety disorders. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which dosing protocol they typically recommend for anxiety-primary patients during your consult.
View all REMS-certified Spravato clinics in Tennessee and across the United States.
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Healing Maps Editorial Staff
View all posts by Healing Maps Editorial StaffThe Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
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