6 Best Ketamine Clinics in Denver (2026) — Verified & Reviewed

• By Healing Maps Editorial Staff
• April 23, 2026April 27, 2026
• Ketamine Articles ketamine therapy ketamine treatment
• With 0 comments

Best Ketamine Clinics in Denver

Denver anchors the entire Front Range and the broader Rocky Mountain interventional-psychiatry market — a Mile-High metro of roughly 3 million residents drawing patients from across Colorado and the broader Rocky Mountain West. Six ranked Denver-metro clinics span anesthesiologist-on-site IV at a published $325/session, addiction-psychiatry-led ketamine, neurology-MD-PhD-led brain health, board-certified psychiatry, multi-state Klarisana, and 15-year-veteran PMHNP-led care. The clinical-philosophy spread is among the broadest in our entire Best-Of series.

3 things to know about Denver ketamine access in 2026

1. Vitalitas Denver publishes the cleanest single-session IV ketamine pricing in the Rocky Mountain West — $325 with no multi-session commitment. Vitalitas Denver Ketamine Center publishes $325 per IV ketamine infusion with no multi-session commitment required — meaning patients can start with a single session and decide week-by-week whether to continue. Most U.S. ketamine clinics require committing to a 6-session protocol upfront. The single-session, anesthesiologist-on-site model lowers the cost-of-trial significantly: patients can experience the medication once for $325 instead of paying $2,000+ upfront for an unproven response.

2. Denver has both addiction-psychiatry-led ketamine and neurology-MD-PhD-led brain health — two highly specialized clinical lenses. Confluence Psychiatry is led by Dr. Charles Shuman, MD (General & Addiction Psychiatry) — a dual-board-certified credential meaningful for patients with co-occurring substance use disorder and treatment-resistant depression. Neuro-Luminance Brain Health Centers is led by Dr. Theodore Henderson, MD, PhD — combining neurology training with research-PhD depth, an MD/PhD credential rare in any ranked Best-Of city. For complex cases, Denver’s specialized clinical leadership is unusually deep.

3. Denver pulls patients from the entire Rocky Mountain West — and that catchment shapes scheduling. Denver isn’t just Colorado’s interventional-psychiatry hub — it’s a regional hub for Wyoming, western Nebraska, western Kansas, parts of New Mexico, and even Montana for patients seeking modalities not locally available. With six ranked Denver clinics covering Spravato (insurance-covered at multiple sites), single-session IV at $325, addiction psychiatry, neurology brain health, multi-state Klarisana, and 15-year-veteran PMHNP care, the regional draw means scheduling can run tighter than the metro size alone suggests — particularly at the lower-cost-of-trial entry points like Vitalitas.

Denver Ketamine Access Snapshot

Behind this data: Behind these numbers: FDA Spravato REMS provider data, HealingMaps’ verified Denver-metro clinic listings (cross-referenced with clinic-published pricing pages and team biographies), Klarisana multi-state network public information, CDC BRFSS Colorado mental-health prevalence, U.S. Census ACS for Denver-Aurora-Lakewood MSA, and HealingMaps’ national IV ketamine pricing scrape (n=65 clinics with confirmed per-session rates).

What this means for you: Denver gives Mountain West patients real philosophical and financial breadth — six ranked clinics span single-session IV at the U.S. median price, multi-session protocols, addiction-psychiatry-led ketamine, neurology MD/PhD brain health, multi-state Klarisana, and PMHNP-led integrative care. The practical decision usually turns on cost-of-trial preference (Vitalitas’s single-session entry vs. multi-session protocols), clinical-specialty match (addiction psychiatry vs. neurology vs. integrative), and insurance fit for Spravato. Use the calculator below to model your scenario.

Denver, Colorado Ketamine Treatment Cost Calculator

Denver Ketamine Clinics At-a-Glance

1. Klarisana

Known For: Klarisana is a pioneering multi-location ketamine therapy provider that has been treating chronic pain and mental health conditions since 2015. The Denver location offers IV ketamine infusions and ketamine-assisted psychotherapy (KAP) in a clinical setting focused primarily on severe depression, PTSD, anxiety, and chronic pain. With over 260 reviews and locations across multiple states, Klarisana brings institutional scale and deep clinical experience to each patient encounter.

Why We Picked Them: Klarisana brings a multi-state ketamine network reputation to downtown Denver, with a dedicated ketamine practice that emphasizes personalized treatment plans and a warm, welcoming clinical environment rather than the sterile infusion-center model. Their Parker Road location near Cherry Creek gives south-central Denver patients a convenient urban option.

Part of a multi-state Klarisana network with locations across Texas, Colorado, Oklahoma, and Louisiana — meaning operational sophistication, refined protocols, and continuity of care for patients who travel.

2. Progressive Psychiatry

Known For: Progressive Psychiatry was the first clinic in Denver to specialize in ketamine treatments, and has nearly a decade of experience with thousands of patients treated. Led by board-certified psychiatrist Dr. Sara Markey, the practice combines IV ketamine infusions with full psychiatric medication management and psychotherapy. Their psychiatrist-led team cites a 70% effectiveness rate for ketamine in treating depression, consistent with published research.

Why We Picked Them: Progressive Psychiatry is led by Dr. Sara Markey, MD — a board-certified psychiatrist delivering ketamine within a full psychiatric medical home rather than as a standalone infusion service. That integration means patients get medication management, psychiatric evaluation, and ongoing follow-up alongside their ketamine treatment, which matters clinically because ketamine works best when paired with ongoing psychiatric care.

Washington Park / East Exposition location accessible from Cherry Creek, Capitol Hill, and the Denver Tech Center corridor via I-25.

3. Confluence Psychiatry

Known For: Confluence Psychiatry is the private practice of Dr. Charles Shuman, a board-certified psychiatrist with dual specializations in general psychiatry and addiction psychiatry. Operating since 2016, Dr. Shuman has completed 150 hours of didactic training in psychedelic-assisted therapy through Colorado’s Integrated Psychiatric Institute. The practice offers ketamine-assisted therapy with transparent, accessible pricing and a thoughtful, evidence-based protocol.

Why We Picked Them: Confluence Psychiatry is led by Dr. Charles Shuman, MD, a psychiatrist specializing in both general AND addiction psychiatry — a dual specialty that’s particularly valuable for patients whose treatment-resistant depression coexists with substance use disorder. The Auraria Parkway location in downtown Denver is walkable from LoDo and accessible from the Auraria higher-education corridor.

Dual-specialty addiction psychiatry training means Confluence can treat patients other ketamine clinics shy away from due to co-occurring substance use concerns.

4. Vitalitas Denver Ketamine Center

Known For: Vitalitas Denver has been treating patients with IV ketamine since early 2016, making it one of Colorado’s longest-running ketamine clinics. The practice is distinguished by having a physician anesthesiologist present for every infusion—a safety standard that few competitors match—and by offering some of the lowest pricing in the country at $325 per infusion with no multi-session commitment required. Having treated hundreds of patients, Vitalitas has deep experience with treatment-resistant cases.

Why We Picked Them: Vitalitas Denver Ketamine Center in Littleton is differentiated by having a physician anesthesiologist on-site for every infusion — a level of monitoring that goes beyond the nurse-led infusion model most ketamine clinics use. Anesthesia-trained physicians understand ketamine pharmacology at a level general psychiatric providers often cannot match, particularly for complex cases involving cardiovascular concerns or medication interactions.

Littleton location serves south Denver metro, Highlands Ranch, Centennial, and the Southwest Denver corridor.

5. Neuro-Luminance Brain Health Centers

Known For: Neuro-Luminance Brain Health Centers is a physician-owned facility co-founded by Dr. Theodore Henderson that combines advanced neuroimaging diagnostics with ketamine infusion therapy. The clinic treats patients from across the nation for neurological, psychiatric, and brain-based disorders, using modern neuroscience imaging to create custom treatment plans. With over 400 patients treated and an 85% reported response rate, the clinic brings a data-driven, research-informed approach to ketamine therapy.

Why We Picked Them: Neuro-Luminance Brain Health Centers is led by Dr. Theodore Henderson, MD, PhD — a neuroscience-researcher-turned-clinician whose publications on ketamine for treatment-resistant depression put him in a different credential tier than most ketamine providers. The Yosemite Street location in the Denver Tech Center serves the southeast metro and brings academic-grade clinical rigor to private practice.

Dr. Henderson’s MD-PhD combination and published research on ketamine pharmacology are uncommon outside academic medical centers.

6. Balanced Mental Wellness

Known For: Balanced Mental Wellness is founded by Chelsie Monroe, a board-certified Psychiatric Mental Health Nurse Practitioner with over 15 years of experience. The Englewood practice offers ketamine-assisted psychotherapy alongside comprehensive psychiatric care, with a strong emphasis on personalized, integrative treatment plans. The clinic has earned enthusiastic patient loyalty for its compassionate approach and life-changing ketamine outcomes.

Why We Picked Them: Balanced Mental Wellness in Englewood is led by Chelsie Monroe, PMHNP-BC, a psychiatric nurse practitioner with 15+ years of experience — providing a more accessible boutique alternative to the physician-led practices in the Denver market. Her Sherman Street location serves south Denver, Englewood, and the Greenwood Village corridor.

PMHNP-led model often means more patient time per visit, more scheduling flexibility, and lower out-of-pocket costs than MD-led boutique practices.

Ketamine Treatment FAQs

Does insurance cover ketamine treatment in Denver?

Spravato (esketamine) is insurance-billed at multiple ranked Denver clinics. IV ketamine is generally self-pay. Vitalitas Denver Ketamine Center publishes $325 per single IV infusion — and notably does not require a multi-session commitment, lowering the cost-of-trial significantly compared to clinics requiring a $2,000+ upfront 6-session protocol.

How much does a single IV ketamine session cost in Denver?

Vitalitas Denver Ketamine Center publishes $325 per single IV infusion with no multi-session commitment required — meaning patients can start with one session and decide week-by-week whether to continue. Neuro-Luminance Brain Health Centers offers single infusions from $435. Most U.S. ketamine clinics require committing to a 6-session protocol upfront; Denver’s single-session entry options are unusual.

How much does a 6-session IV ketamine induction series cost in Denver?

At Vitalitas’s $325/session rate, a 6-session induction runs $1,950 cash — slightly below the U.S. patient-reported median. Other Denver clinics quote based on protocol design. Use the Denver Ketamine Treatment Cost Calculator above to model your specific scenario.

Can I get ketamine alongside addiction psychiatry care in Denver?

Yes — Confluence Psychiatry is led by Dr. Charles Shuman, MD, who is dual-board-certified in General Psychiatry AND Addiction Psychiatry. For patients with co-occurring substance use disorder and treatment-resistant depression, this dual board certification means ketamine treatment decisions are made within a clinician’s full understanding of addiction medicine — rare nationally.

What is special about Neuro-Luminance’s clinical leadership?

Neuro-Luminance Brain Health Centers is led by Dr. Theodore Henderson, MD, PhD — combining neurology training with research-PhD depth. The MD/PhD credential is rare in any ranked Best-Of city and signals research-driven clinical decision-making. For patients with neurological co-occurring conditions or who prioritize research-trained clinical leadership, this is a distinct option.

Where do patients commute from for Denver ketamine care?

Denver is the Rocky Mountain West’s anchor interventional-psychiatry metro. Patients routinely commute from across Colorado (Colorado Springs, Fort Collins, Greeley), Wyoming, western Nebraska, western Kansas, northern New Mexico, and parts of southern Montana — for modalities or specialty care not locally available.

Does Denver have a ketamine-assisted psychotherapy (KAP) program?

Several Denver-metro psychiatric and integrative practices offer KAP. Boulder (also covered in our Best-Of series) has stronger formal KAP focus with retreat-style and cannabis-assisted KAP options nearby. For patients in the Denver metro specifically, several ranked clinics integrate therapy with ketamine; verify KAP availability directly at intake.

Explore More: Best Ketamine Clinics by City

Looking for ketamine clinics in another city? Browse our full series of verified clinic guides across the United States.