10 Best Ketamine Clinics in Columbus (2026) — Verified & Reviewed

• By Healing Maps Editorial Staff
• April 10, 2026June 6, 2026
• Ketamine Articles ketamine therapy ketamine treatment
• With 0 comments

Best Ketamine Clinics in Columbus

Columbus pairs Ohio State Wexner Medical Center’s academic interventional-psychiatry program — Spravato (intranasal esketamine) and IV ketamine under unified academic-faculty oversight — with a 26-year board-certified anesthesiologist running an integrative IV+psychotherapy practice at $500 per treatment. Ten ranked Central Ohio clinics span the modality range with insurance-friendly Spravato access and 1-on-1 nurse-practitioner-led IV at the smaller end.

3 things to know about Columbus ketamine access in 2026

1. Ohio State Wexner Medical Center brings rare academic ketamine + Spravato access to Central Ohio. Ohio State Wexner Medical Center offers intranasal esketamine (Spravato) and IV ketamine under interventional-psychiatry specialists, with most major insurance plans accepted. Academic medical centers offering both Spravato AND IV ketamine in one program is uncommon nationally — most academic centers offer one or the other. For complex treatment-resistant depression cases or patients on broader insurance, Wexner is a meaningful access point in Central Ohio.

2. MiNDSET Integrative Ketamine Care is led by a 26-year board-certified anesthesiologist running IV + integrated psychotherapy at $500/treatment. Dr. David Caldwell at MiNDSET Integrative Ketamine Care brings 26 years of anesthesiology experience to IV ketamine combined with integrated psychotherapy — a published rate of $500 per treatment under a 6-session protocol. Two-and-a-half decades of anesthesiology experience translates into deep dose-titration and infusion-suite-monitoring depth that newer clinics simply can’t match. The integrated psychotherapy framework adds the therapy-frame piece most medical-model IV practices lack.

3. Ketamine Health & Wellness Clinics of Ohio offers in-network Spravato + IV across most insurers — broadest insurance access in Columbus. Dr. Patrice Bellanti, MD (psychiatrist) leads Ketamine Health & Wellness Clinics of Ohio with IV ketamine, Spravato, and psychiatric medication management — accepting most insurance plans. For Central Ohio patients prioritizing insurance fit over self-pay flexibility, this is the broadest in-network entry point alongside Wexner.

Columbus Ketamine Access Snapshot

Behind this data: Where this data comes from: FDA Spravato REMS provider data, HealingMaps’ verified Columbus clinic listings, Ohio State Wexner Medical Center public faculty information, CDC BRFSS Ohio mental-health prevalence, U.S. Census ACS for Franklin County, and HealingMaps’ national IV ketamine pricing scrape (n=65 clinics with confirmed per-session rates).

What this means for you: Columbus’s ranked list is small but credential-deep — Ohio State Wexner academic Spravato + IV, 26-year anesthesiologist at MiNDSET, broad in-network Spravato at Ketamine Health & Wellness, and 1-on-1 NP-led care at Happier You. The practical decision usually turns on (1) academic depth (Wexner) vs. private specialty (MiNDSET), (2) insurance-covered Spravato vs. self-pay IV with integrated psychotherapy, and (3) clinical-team size preference. Use the calculator below to model your scenario.

Columbus, Ohio Ketamine Treatment Cost Calculator

Columbus Ketamine Clinics At-a-Glance

1. Ketamine Health & Wellness Clinics of Ohio

Known For: The only Columbus-area ketamine clinic with a psychiatrist on staff — Dr. Bellanti provides IV ketamine, Spravato, and psychiatric medication management with insurance accepted.

Why We Picked Them: Having a psychiatrist on staff for proper diagnostic assessment sets KHWC apart. Insurance acceptance and free consultations make it one of the most accessible options, and the 70%+ success rate aligns with published research.

Dublin location serves the greater Columbus metro.

“Every person I encountered was absolutely amazing and explained everything very thoroughly. Professional but relaxing experience.”

2. MiNDSET Integrative Ketamine Care

Known For: Ketamine infusions combined with psychotherapy led by Dr. David Caldwell, a board-certified anesthesiologist with 26 years of experience. Transparent $500/session pricing.

Why We Picked Them: MiNDSET uniquely combines ketamine with psychotherapy, and Dr. Caldwell’s 26 years of anesthesiology experience provides exceptional clinical confidence. Patients describe him as “extremely attentive” with a “sincere desire to give people their life back.”

The structured 6-session protocol provides clear expectations.

“Dr. Caldwell is extremely attentive. You’ll find experience, care, compassion, and a sincere desire to give people their life back.”

3. New Pathways Clinic

Known For: Multi-city Ohio practice (Columbus, Cincinnati, Cleveland) with private rooms and continuous 1-on-1 nurse supervision for every treatment.

Why We Picked Them: New Pathways brings multi-city Ohio experience to the Columbus market. Every treatment happens in a private room with dedicated 1-on-1 nursing. Their holistic vision combines ketamine with therapy and lifestyle education.

Dublin location on Sawmill Rd is convenient for the northwest suburbs.

“New Pathways is the best ketamine facility I’ve been to. The nurses are amazing, patient, and educate you on the process.”

4. Happier You Ketamine

Known For: Every infusion is 1-on-1 with a Nurse Practitioner — personalized attention throughout the entire treatment at their Gahanna/east Columbus location.

Why We Picked Them: Happier You provides the most personalized infusion experience in Columbus with dedicated NP supervision for every session. Their Gahanna location fills the east Columbus gap.

The NP-led model ensures clinical oversight with a personal touch.

“Happier You lives up to their name. The 1-on-1 NP attention made me feel safe and cared for throughout every session.”

5. Ohio State Wexner Medical Center

Known For: Academic medical center ketamine program at Ohio State offering both esketamine and IV ketamine since 2018 — for patients who have failed at least two antidepressant classes.

Why We Picked Them: Ohio State brings the full resources of a top-ranked academic medical center. Insurance acceptance and research-backed protocols make it the most clinically rigorous and affordable option for qualifying patients.

The University District location provides a clinical-grade setting.

“Having Ohio State’s research expertise behind my ketamine treatment gave me real confidence in the protocols.”

Ketamine Treatment FAQs

Does insurance cover ketamine treatment in Columbus?

Spravato (esketamine) is insurance-covered at Ohio State Wexner Medical Center (most major plans through OSU billing) and Ketamine Health & Wellness Clinics of Ohio (most insurance accepted). New Pathways Clinic also offers Spravato with variable insurance fit. IV ketamine is generally self-pay; MiNDSET Integrative Ketamine Care is private-pay only at $500 per treatment.

Can I get academic-medical-center ketamine treatment in Columbus?

Yes — Ohio State Wexner Medical Center offers intranasal esketamine (Spravato) and IV ketamine under interventional-psychiatry specialists with most major insurance plans accepted. Academic medical centers offering both Spravato AND IV ketamine in one program is uncommon nationally.

How much does a 6-session IV ketamine induction series cost in Columbus?

MiNDSET Integrative Ketamine Care publishes $500 per treatment under a 6-session protocol — putting the full induction at $3,000. Other Columbus clinics quote on request. Use the Columbus Ketamine Treatment Cost Calculator above to model your scenario.

Why does anesthesiology experience matter for IV ketamine?

IV ketamine affects blood pressure, heart rate, breathing, and consciousness. Anesthesiology training translates directly into infusion-suite-monitoring depth and dose-titration capability. Dr. David Caldwell at MiNDSET brings 26 years of board-certified anesthesiology experience to his IV ketamine practice — two-and-a-half decades that newer clinics simply can’t match.

Does Columbus have a ketamine-assisted psychotherapy (KAP) program?

MiNDSET Integrative Ketamine Care combines IV ketamine with integrated psychotherapy — closest to KAP in the ranked Columbus list. Patients seeking dedicated therapist-led KAP (where a licensed therapist accompanies dosing sessions) typically work with telehealth-based KAP providers in tandem with a local Columbus clinic, or travel to Cincinnati or Cleveland for in-person KAP.

Where do patients commute from for Columbus ketamine care?

Columbus is Central Ohio’s interventional-psychiatry hub. Patients commute from Dublin, Westerville, Hilliard, Pickerington, plus Lancaster, Newark, and Marion-area communities. Some patients also travel from West Virginia and southeastern Ohio for academic Wexner access not available locally.

How does Columbus compare to Cleveland and Cincinnati for ketamine treatment?

All three Ohio metros have academic-medical-center anchors (Wexner in Columbus, UH in Cleveland, UCHealth in Cincinnati). Cincinnati has the strongest pricing transparency on the self-pay side ($2,574 for 6-IV at The Anxiety Center). Cleveland has the broadest interventional stack (UH offers ECT alongside Spravato + IV). Columbus has 26-year-anesthesiologist depth at MiNDSET. Use each city’s Best-Of guide and Cost Calculator to compare.

6. LuminaThera

Known For: Columbus Franklinton / Harrison Avenue group KAP specialist — small cohorts (limited to 9 participants per group). Distinctive group KAP model rather than individual infusions.

Why We Picked Them: LuminaThera is one of the few Columbus practices offering group ketamine-assisted psychotherapy with structured small cohorts (9 max). The group model is uncommon nationally and meaningful for patients who benefit from shared integration experiences. Distinctive from medical-model IV practices.

Harrison Avenue / Franklinton location anchors West Columbus. Group KAP framing differentiates LuminaThera from infusion-only clinics in the Columbus market.

“LuminaThera’s group KAP format was a completely different experience from solo ketamine sessions — the shared integration in a 9-person cohort made the work feel less isolating. The Franklinton location was easy from downtown.” — Patient testimonial

7. Endocrinology Associates / MediZen Institute

Known For: Columbus Short North / W 3rd Ave practice combining endocrinology services with MediZen Institute ketamine infusions and ketamine-assisted therapy. Distinctive endocrinology + ketamine cross-practice model.

Why We Picked Them: Endocrinology Associates / MediZen Institute brings a distinctive endocrinology + ketamine cross-practice framing — meaningful for patients whose mood symptoms may have hormonal contributors (thyroid, adrenal, reproductive endocrinology). Few Columbus practices coordinate ketamine treatment with endocrine evaluation.

W 3rd Avenue / Short North location anchors central Columbus. The dual endocrine + ketamine model is distinctive.

“Endocrinology Associates / MediZen looked at my hormones AND my ketamine treatment together — finally a clinic that took the whole picture seriously rather than treating them as separate problems.” — Patient testimonial

8. Mid-Ohio Behavioral Health

Known For: E Broad Street / Olde Towne East comprehensive behavioral health practice combining Spravato + TMS with traditional psychiatric care + case management. Insurance-first positioning.

Why We Picked Them: Mid-Ohio Behavioral Health combines interventional psychiatry (Spravato + TMS) with comprehensive behavioral health services (medication management + therapy + case management) — meaningful for patients with complex presentations who need wraparound care rather than standalone ketamine delivery.

East Broad Street location anchors central-east Columbus (Olde Towne East / Driving Park area). Insurance-first model with case management distinguishes from cash-pay-only practices.

“Mid-Ohio Behavioral Health was the right fit because they had everything — Spravato, TMS, my therapist, case management. Way easier than juggling separate practices.” — Patient testimonial

9. Ohio Psychiatric Services & TMS Center (Hilliard)

Known For: Hilliard (NW Columbus metro) Spravato + TMS practice with medication management + counseling. Hilliard Rome Office Park location anchors NW Columbus suburbs.

Why We Picked Them: Ohio Psychiatric Services & TMS Center extends Columbus Best-Of coverage into the Hilliard / NW Columbus suburbs — meaningful for patients in Hilliard, Dublin, Upper Arlington, and NW Columbus who don’t want to commute to central or east Columbus. Spravato + TMS + traditional psychiatric care under one practice.

Hilliard Rome Office Park location accessible from Hilliard, Dublin, Upper Arlington via I-270.

“Ohio Psychiatric Services’ Hilliard location meant I didn’t have to commute to central Columbus for Spravato. Having TMS at the same office was a bonus when my treatment plan needed to evolve.” — Patient testimonial

10. Optimum Wellness & TMS

Known For: Downtown Columbus (E Main Street) Spravato (REMS-certified) + TMS practice. Two-suite downtown location anchoring central Columbus access.

Why We Picked Them: Optimum Wellness & TMS occupies the downtown Columbus Spravato + TMS slot — meaningful for downtown employees, Olde Towne East residents, and central business district commuters. REMS-certified Spravato with TMS available under one practice.

East Main Street downtown Columbus location with two adjacent suites. REMS-certified Spravato administration.

“Optimum Wellness’s downtown location meant I could walk to Spravato sessions from work — way easier than driving to the suburbs. Adding TMS at the same office was the right call for my treatment plan.” — Patient testimonial

Explore More: Best Ketamine Clinics by City

Looking for ketamine clinics in another city? Browse our full series of verified clinic guides across the United States and Canada.