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HealingMaps Take: Ohio State’s Wexner Medical Center brings the full resources of a top-ranked academic medical center to ketamine therapy. Operating since 2018, their interventional psychiatry team offers both intranasal esketamine and IV ketamine for patients who have failed at least two antidepressant classes. Insurance acceptance and academic rigor make it a strong option. For more options, see our guide to finding the best ketamine therapy clinics.

Market Position: Ohio State Wexner Medical Center is a Spravato-certified clinic in the Columbus metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.

Ohio State Wexner Medical Center Ketamine Cost Calculator

Ketamine Protocols Compared — What’s Offered at Ohio State Wexner Medical Center

Industry pricing reference. Ohio State Wexner Medical Center has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.

What to Expect at Your First Ohio State Wexner Medical Center Appointment

1. Initial intake call — Insurance verification, prior authorization workflow (Spravato requires documentation of failure on at least two antidepressant trials), and clinical eligibility check.
2. Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Ohio State Wexner Medical Center clinical team.
3. First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at 410 W 10th Ave, Columbus, OH 43210. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
4. Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.

What to Ask on Your Ohio State Wexner Medical Center Consult Call

• How long has the Ohio State Wexner Medical Center clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
• Walk me through Ohio State Wexner Medical Center’s Spravato prior authorization process versus your IV ketamine cash-pay or superbill workflow — which is the better fit for my insurance situation?
• Have you coordinated with Ohio’s major insurer networks (Anthem, UnitedHealthcare, Medical Mutual) for Spravato authorizations, and how long is your typical timeline?
• Does Ohio State Wexner Medical Center require a referral from a current treating psychiatrist, and how do you handle outside-prescriber medication-management coordination?
• What does Ohio State Wexner Medical Center recommend for patients who don’t respond to the standard 6-session acute series?

Patient Questions about Ohio State Wexner Medical Center

This 4-question summary is matched to the protocols and conditions Ohio State Wexner Medical Center treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.

What ketamine protocols does Ohio State Wexner Medical Center offer?

Ohio State Wexner Medical Center offers Spravato and IV ketamine — a 2-protocol practice. Patients can switch between or combine modalities without changing providers. Confirm specific dosing schedules and which protocols are recommended for your condition during your consult.

Does Ohio State Wexner Medical Center offer Spravato (esketamine)?

Yes — Ohio State Wexner Medical Center offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.

Is Ohio State Wexner Medical Center suited for treatment-resistant depression?

Ohio State Wexner Medical Center treats depression via Spravato (FDA-approved for TRD), and IV ketamine (off-label, evidence-based). The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.

Does Ohio State Wexner Medical Center treat PTSD?

Yes — Ohio State Wexner Medical Center treats PTSD. Both Spravato and IV ketamine can be used for trauma. Ketamine for trauma differs from depression treatment: dosing is often lower per session, and pairing the protocol with trauma-focused therapy between sessions is common. A reasonable consult question: whether PTSD patients here typically use ketamine alone or alongside an outside therapist.