7 Best Ketamine Clinics in Philadelphia (2026) — Verified & Reviewed

• By Healing Maps Editorial Staff
• September 13, 2023May 11, 2026
• ketamine therapy ketamine treatment ketamine treatment philadelphia
• With 0 comments

Last reviewed and updated: May 11, 2026.

Pricing benchmarks below reflect our 2026 national dataset; Philadelphia-specific clinic data appears in the rankings further down this article.

The pricing benchmarks below are the national reference. Philadelphia’s academic-medicine concentration tends to keep its rates closer to the national median than coastal-metro markets.

Ketamine is becoming a source of hope for those seeking to overcome mental health challenges and chronic pain. Rising to meet demand, clinics have been popping up all around the country. Philadelphia is no exception. And to help you find the most effective and safe treatment we made this list of the best ketamine clinics in Philadelphia.

For some people, a helpful ketamine treatment can take effect as quickly as a few hours. Notoriously difficult-to-treat conditions like depression, anxiety, PTSD, bipolar and pain may benefit from ketamine treatment. 

Ketamine can be expensive and is rarely covered by insurance. But there is a chance for lasting or at least temporary relief from symptoms. Embarking on a ketamine treatment will take place over several weeks with multiple sessions in a clinic. So, it’s important to find a team you trust.

RELATED: Ketamine Treatment: Everything You Need to Know from Costs to Benefits for Depression, Anxiety and More

7 Best Ketamine Clinics in Philadelphia: How We Created the List

We built the list below by reading reviews, learning about the founders, their background, the staff and the clinic’s approach. For example: ketamine doesn’t solve everyone’s problems, but it can be a lifeline. 

One way of thinking about ketamine is creating a window of opportunity. To step through that new opening, therapeutic support seems to help people process ketamine and make changes. That is why we look to see if clinics work with mental health professionals or if integration and preparation sessions are included in packages. Not every center on this list includes therapy, so be sure to consider this factor before making a final choice. Some clinics are also focused on pain, in which case therapeutic support is not as important.

There are now many centers to choose from throughout Philadelphia, Pittsburgh and the rest of Pennsylvania. We recommend doing lots of research and reaching out to several clinics before making a final decision. These are the best ketamine clinics in Philadelphia, based on our research.

1. Philadelphia Integrative Psychiatry

Known For: 4.9 stars across 151+ reviews with the widest range of ketamine delivery methods in Philadelphia — IV, IM, intranasal, oral, and Spravato

Find a REMS-certified Spravato clinic near you in our verified provider directory.

Why We Picked Them: Philadelphia Integrative Psychiatry leads the region with a 4.9-star average across 151+ reviews and the most delivery options of any clinic on this list — IV, IM, intranasal, oral, and Spravato. Their KAP packages bundle preparation and integration sessions, ensuring the therapeutic work surrounding each treatment is as intentional as the infusion itself.

Co-founded by Dr. David Danish and John Guardiani, the practice also offers TMS for patients who may benefit from a non-ketamine approach. Located in Devon on the Main Line, they serve the greater Philadelphia metro. Spravato is covered by insurance, and CareCredit financing makes IV ketamine more accessible for cash-pay patients.

“Philadelphia Integrative changed my life. The KAP sessions helped me process years of trauma in ways talk therapy alone never could.” — Google Review

2. Voyage Healing

Known For: Psychiatrist-founded KAP practice accepting major insurance (Aetna, United, Highmark BCBS, Cigna) with five ketamine delivery methods

Why We Picked Them: Dr. Gail Serruya brings over 20 years of psychiatric experience and has built Voyage Healing around genuine therapeutic integration. The practice accepts major insurance plans — Aetna, United, Highmark Blue Cross, and Cigna — making KAP financially accessible in a way most competitors can’t match. Five delivery methods (IV, IM, subcutaneous, oral, Spravato) ensure each patient gets the right fit.

With locations in both Philadelphia and Bala Cynwyd, Voyage serves the city and surrounding suburbs. Their $100 discount for combining IM or oral ketamine with KAP incentivizes the therapeutic approach they believe produces the best outcomes. The practice uses the Osmind app for streamlined billing and patient tracking.

“Dr. Serruya is compassionate and knowledgeable. The KAP sessions at Voyage Healing have been the most impactful treatment I’ve ever received.” — Google Review

3. SoundMind Institute

Known For: Nonprofit KAP clinic with a psychoanalytic approach — each session includes prep, a 2-3 hour guided experience, and integration with a peer support program for veterans

Why We Picked Them: SoundMind Institute is unlike any other clinic on this list — a 501(c)(3) nonprofit founded by Dr. Hannah McLane, a Brown and Harvard-trained physician and relational psychoanalyst. Their model emphasizes deep therapeutic work: each session includes preparation, a 2-3 hour guided oral ketamine experience, and integration. They require patients to maintain an outside therapist, ensuring continuity of care.

The institute enrolls patients in cohorts (April and September 2026), creating a community-based treatment structure. Their veteran peer support program adds a unique layer of care for service members. While the oral-only approach won’t suit every patient, those seeking a deeply therapeutic, research-informed KAP experience will find SoundMind exceptionally compelling.

“SoundMind’s approach is deeply intentional. The preparation and integration work made the ketamine sessions far more meaningful than just an infusion.” — Patient Testimonial

4. Genesis Ketamine Centers

Known For: UPenn-trained, double board-certified founder specializing in both pain medicine and anesthesiology — with a Fort Lauderdale second location

Why We Picked Them: Dr. Samuel Grodofsky brings elite credentials — double board certification in pain medicine and anesthesiology with UPenn training. This dual expertise is particularly valuable for patients dealing with both chronic pain and mood disorders, as Dr. Grodofsky understands the neurological intersection of both conditions.

Genesis Ketamine Centers also operates a Fort Lauderdale location, demonstrating the practice’s growth and stability. A free consultation and payment plans help make treatment accessible despite the cash-pay model. The Bala Cynwyd location is easily accessible from Center City Philadelphia via the Schuylkill Expressway.

“Dr. Grodofsky is incredibly knowledgeable and made me feel completely safe throughout the process. The results have been remarkable.” — Google Review

5. Ketamine of Philadelphia

Known For: UPenn Hospital-affiliated psychiatrist providing IV ketamine in the heart of Center City Philadelphia

Why We Picked Them: Dr. John Applegate brings 15+ years of psychiatric experience and UPenn Hospital staff privileges to his ketamine practice. Located in the Fairmount/Art Museum area of Center City, the clinic offers a convenient urban location that many suburban-based competitors can’t match. His psychiatric background means patients receive infusions under the direct supervision of a specialist who understands the full clinical picture.

While the practice focuses exclusively on IV ketamine infusions (no KAP or alternative delivery methods), Dr. Applegate also evaluates patients for TMS, providing a referral pathway for those who may benefit from a different treatment approach. The streamlined, infusion-focused model keeps the experience efficient and clinically precise.

“Dr. Applegate is thorough, knowledgeable, and genuinely cares about his patients. The ketamine treatments have made a significant difference in my depression.” — Google Review

6. Relievus Pain Management

Known For: Multi-location pain management practice offering IV ketamine specifically for chronic pain conditions like CRPS, neuropathy, and fibromyalgia

Why We Picked Them: Relievus fills an important niche as a pain management-focused ketamine provider. While most clinics on this list emphasize mood disorders, Relievus specializes in chronic pain conditions like CRPS, neuropathy, and fibromyalgia — making it the go-to option for patients whose primary concern is pain rather than depression or anxiety.

As a multi-location pain management chain, Relievus brings established protocols and experienced staff to ketamine infusion delivery. Their 45-60 minute infusion sessions are administered by pain specialists who understand the specific dosing and monitoring needs of chronic pain patients. Located in Northeast Philadelphia on Roosevelt Boulevard, the clinic is accessible from across the city.

“The ketamine infusions at Relievus have significantly reduced my chronic pain levels. The staff is professional and attentive throughout each session.” — Patient Testimonial

7. Mindstream Medicine

Known For: Fishtown’s integration-first ketamine clinic with transparent pricing ($400-$450) and a requirement that all patients maintain ongoing talk therapy

Why We Picked Them: Mindstream Medicine takes a uniquely principled approach — they require all patients to be in ongoing talk therapy before beginning ketamine treatment, ensuring the infusions complement rather than replace traditional therapeutic work. Dr. Evan Husted, a board-certified emergency medicine physician with an MPH, brings both clinical expertise and a public health perspective.

Located in Philadelphia’s trendy Fishtown neighborhood, the clinic offers both IV ($450) and IM ($400) ketamine at competitive, transparent prices. Their integration-focused philosophy means patients are supported before, during, and after treatment. The EM background of the clinical lead provides an extra layer of safety monitoring during infusions.

“Dr. Husted is incredibly thoughtful and thorough. Requiring talk therapy alongside ketamine shows they truly care about lasting outcomes, not just quick fixes.” — Google Review

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