PAX Institute – Sioux Falls, South Dakota Ketamine Clinics

Known For: Full-service psychiatric practice offering both IV ketamine and Spravato alongside comprehensive psychiatry. Evening hours from 12 PM to 8 PM.

HealingMaps Take: PAX Institute stands out in the Sioux Falls market as the most comprehensive treatment option — the only provider in South Dakota offering both IV ketamine infusions and Spravato (esketamine nasal spray) under the same roof as full psychiatric services. This matters because ketamine treatment does not exist in a vacuum; patients benefit enormously when their infusion provider can also manage medications, adjust treatment plans, and monitor psychiatric progress in an integrated care model. Led by Veronica Sherwood, PMHNP, and Molly Mortenson as Director of Pharmacotherapy, the practice brings specialized expertise to a region that has historically lacked it. The evening hours — 12 PM to 8 PM — are a thoughtful accommodation for working patients who cannot take mornings off for treatment. For patients who want a psychiatric home that happens to offer ketamine, rather than a ketamine clinic that refers out for everything else, PAX Institute is the clear choice in South Dakota.

Patient Review

“The team at PAX Institute provided exceptional, personalized treatment that addressed my depression from every angle. Having psychiatry and ketamine therapy in one place meant I didn’t have to coordinate between multiple providers.”

About PAX Institute

PAX Institute is a full-service psychiatric and pharmacotherapy practice located at 6709 S Minnesota Ave, Suite 101, in Sioux Falls, South Dakota. The clinic offers IV ketamine infusions, Spravato (intranasal esketamine), and comprehensive psychiatric services including medication management. The practice is led by Veronica Sherwood, PMHNP, with Molly Mortenson serving as Director of Pharmacotherapy. PAX Institute treats depression, anxiety, PTSD, OCD, chronic pain, and postpartum depression. The clinic operates evening hours from 12 PM to 8 PM, making treatment accessible for working patients.

For more on how ketamine therapy works, see our complete guide to ketamine therapy.

What People Like

The only South Dakota clinic offering both IV ketamine and Spravato under one roof. Full psychiatric services allow integrated treatment planning — not just infusions. Evening hours (12-8 PM) accommodate working patients. Spravato is often covered by insurance, providing a more affordable pathway for qualifying patients. The dual-provider model with a dedicated Director of Pharmacotherapy signals clinical depth.

What People Don’t Like

KAP (ketamine-assisted psychotherapy) is not offered. Specific pricing for IV ketamine is not published — patients must contact the clinic. The afternoon/evening schedule means no morning appointments are available. As a newer practice in the market, the long-term track record is still developing.

Getting Started at PAX Institute

Call (605) 496-9770 or visit pax-institute.com to schedule a consultation. The clinic is at 6709 S Minnesota Ave, Suite 101, Sioux Falls, SD 57108. Hours are 12 PM to 8 PM. Ask about Spravato insurance coverage during your initial call.

Learn more about the evidence behind ketamine for depression at the National Institute of Mental Health.

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