PAX Institute – Sioux Falls, South Dakota Ketamine Clinics, Spravato Clinics

✓ Last verified: March 8, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff

Known For: Full-service psychiatric practice offering both IV ketamine and Spravato alongside comprehensive psychiatry. Evening hours from 12 PM to 8 PM.

💡 No clinic-specific pricing posted? See our ketamine therapy cost guide for typical pricing ranges by treatment type and insurance pathways.

HealingMaps Take: PAX Institute stands out in the Sioux Falls market as the most comprehensive treatment option — the only provider in South Dakota offering both IV ketamine infusions and Spravato (esketamine nasal spray) under the same roof as full psychiatric services. This matters because ketamine treatment does not exist in a vacuum; patients benefit enormously when their infusion provider can also manage medications, adjust treatment plans, and monitor psychiatric progress in an integrated care model. Led by Veronica Sherwood, PMHNP, and Molly Mortenson as Director of Pharmacotherapy, the practice brings specialized expertise to a region that has historically lacked it. The evening hours — 12 PM to 8 PM — are a thoughtful accommodation for working patients who cannot take mornings off for treatment. For patients who want a psychiatric home that happens to offer ketamine, rather than a ketamine clinic that refers out for everything else, PAX Institute is the clear choice in South Dakota.

Market Position: PAX Institute is a Spravato-certified clinic in the Falls metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.

PAX Institute Ketamine Cost Calculator

Ketamine Protocols Compared — What’s Offered at PAX Institute

Industry pricing reference. PAX Institute has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.

What to Expect at Your First PAX Institute Appointment

1. Initial intake call — Insurance verification, prior authorization workflow (Spravato requires documentation of failure on at least two antidepressant trials), and clinical eligibility check. Call (605) 496-9770 to schedule.
2. Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the PAX Institute clinical team.
3. First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at 6709 S Minnesota Ave, Suite 101, Sioux Falls, SD 57108. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
4. Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.

What to Ask on Your PAX Institute Consult Call

• How long has the PAX Institute clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
• Walk me through PAX Institute’s Spravato prior authorization process versus your IV ketamine cash-pay or superbill workflow — which is the better fit for my insurance situation?
• What does PAX Institute recommend for patients who don’t respond to the standard 6-session acute series?

Falls Ketamine Market Snapshot

Sources: CDC PLACES 2023 (Lincoln County, SD, crude prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.

• Adult depression in Lincoln County, SD: 20.0%
• Frequent mental distress (14+ days per month): 14.0%
• Adults lacking health insurance: 6.8%
• Lincoln County population: 65,801 · median household income $92,317
• Recent Falls-area inquiries to HealingMaps: A growing stream of South Dakota residents have recently contacted us seeking ketamine care

Behind this data: HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,473 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.

From the 2026 Ketamine Industry Report

58.1% of patients say telehealth increases access to ketamine therapy — even among those skeptical of at-home protocols, virtual consultation consistently ranks as a net positive. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.

Patient Questions about PAX Institute

This 6-question summary is matched to the protocols and conditions PAX Institute treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.

What ketamine protocols does PAX Institute offer?

PAX Institute offers Spravato and IV ketamine — a 2-protocol practice. Patients can switch between or combine modalities without changing providers. Confirm specific dosing schedules and which protocols are recommended for your condition during your consult.

Does PAX Institute offer Spravato (esketamine)?

Yes — PAX Institute offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.

Is PAX Institute suited for treatment-resistant depression?

PAX Institute treats depression via Spravato (FDA-approved for TRD), and IV ketamine (off-label, evidence-based). The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.

Does PAX Institute treat chronic pain conditions?

Yes — PAX Institute treats chronic pain. They use IV ketamine for pain, which typically means longer infusion times and higher cumulative doses than mental-health protocols. Common indications include complex regional pain syndrome (CRPS), fibromyalgia, and certain neuropathic pain syndromes. Pain pricing varies significantly by structure: per-infusion vs. multi-day inpatient packages — verify how this clinic structures their billing.

Does PAX Institute treat PTSD?

Yes — PAX Institute treats PTSD. Both Spravato and IV ketamine can be used for trauma. Ketamine for trauma differs from depression treatment: dosing is often lower per session, and pairing the protocol with trauma-focused therapy between sessions is common. A reasonable consult question: whether PTSD patients here typically use ketamine alone or alongside an outside therapist.

Can PAX Institute help with anxiety disorders?

Yes — PAX Institute treats anxiety, including generalized anxiety, social anxiety, and panic disorder. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which of their protocols they typically recommend for anxiety-primary patients.

View all REMS-certified Spravato clinics in South Dakota and across the United States.

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