Ketamine And Marijuana: 3 Things To Know Before Combining Drugs

Ketamine And Marijuana: 3 Things To Know Before Combining Drugs

Ketamine is growing in popularity, with ketamine clinics popping up all over the world as a form of alternative therapy. With research showing amazing results when dealing with severe cases of common mental health issues, expect the practice to expand.

Even though IV treatments aren’t yet FDA regulated, it’s not uncommon for psychotherapists to recommend trying it out. This is due to so many people reporting noticeable, positive changes after only a few sessions.

Marijuana, on the other hand, is not a psychedelic although its classification is definitely unique. Marijuana itself refers to the dried leaves, flowers, stems and seeds from the Cannabis sativa or Cannabis indica plant. Each contains the mind-altering chemical THC and other similar compounds. It has depressant, hallucinogenic and stimulant properties, but it doesn’t neatly fit into any single one of these categories.

As a hallucinogen, it’s closest to other psychedelics, and the question of its effect when combined with one comes into play. Depending on the psychedelic, the dosage and strength may differ. It’s also important to be extra vigilant and careful when taking any combination of drugs.

Ketamine is a dissociative anaesthetic and sedative. Marijuana is a psychoactive drug. How will each react when taken together, and will it yield some kind of positive result? Here’s what we know about mixing the two together.

Potential Enhancement of Negative Side Effects

Since both substances can invoke negative side effects, when taken together, the same could be enhanced. For instance, some users see an increase in closed eye visuals, a tunneling of the mind, more confusion, noticeable dizziness and drowsiness. Likewise, problems with focus and concentration often appear.

When not monitoring both substances together, this creates a problem, as the side effects could potentially cause further harm. If trying this, be sure to have someone nearby who is aware and sober, and can assist unforeseen side effects.

Potential Benefits for Bipolar Disorder

In 2014, the Departments of Psychiatry and Anesthesiology at Kaiser Permanente started the Ketamine Infusion Therapy Program. This offers treatment of both unipolar and bipolar depression. Researchers treated 40 patients with both diagnoses. The results showed one possible ketamine-induced case switch from depression to mixed mania among seven patients with bipolar disorder (n = 4 bipolar disorder type II and n = 3 bipolar disorder type I) treated.

This shows potential when mixing the two under specific circumstances. Further research can help prove whether this is something that could be useful in the future.

Potential Development of Addiction

Ketamine’s addictive potential separates it from other psychedelics. It also rates as being only slightly more addictive than cannabis. Interestingly enough, ketamine addiction is more psychological in nature than physical, which makes it quite similar to cannabis addiction.

When taken in larger doses and abused, ketamine, as a dissociative, provides a sort of escapism. It can successfully separate a user from a sense of self and the world. This can create addictive tendencies, leading to cravings in order to feel a “blissful escape” from reality.

On the other hand, ketamine can also increase positive feelings like euphoria and contentment. These positive states also make it tempting to become a frequent ketamine user, therefore developing a ketamine addiction.

Marijuana’s addiction potential is well-known, with recent data suggesting 30 percent of those who use the drug may have some degree of marijuana use disorder. The use disorder, according to researchers, can morph into addiction when a person can’t stop using the drug even. This happens when it interferes with daily activities, causing severe psychological withdrawal symptoms.

Combining the two can have a significantly higher risk of developing addiction. This may worsen withdrawal symptoms when ending up without the substances.

Whatever the case may be, when it comes to mixing ketamine with marijuana, the research is still in its infancy. Additionally, many of the current trials are still under way. But when using the correct dosage, it can potentially be a great cocktail mix for specific mental health issues. The results will speak for themselves.

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Karla Ilicic

View all posts by Karla Ilicic

Karla is a freelance writer, yoga teacher and nutritionist who's been writing about nutrition, fitness, yoga, mindfulness, and overall health and wellness topics for over seven years. She's written for numerous publications such as Healthline, Livesavvy,, Well + Good, and many others, sharing her love of storytelling and educating. She loves talking about superfoods and another amazing plant powers that people can benefit from if they learn how to use it properly. Her passion lies in helping others not only eat healthier meals but implement good eating habits, find a great relationship with food & achieve a balanced lifestyle. She believes that the only diet and lifestyle that's worth creating is the one you can stick to, so she aims to find what that means for each and every individual. Teaching WHY we eat, and not only WHAT we eat, is the premise of her approach.

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