InnerMost – New York City, New York Ketamine Clinics, Spravato Clinics

✓ Last verified: April 3, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff

Known For: Research-backed psychedelic-assisted therapy led by one of the field’s most experienced ketamine psychiatrists, Dr. Casey Paleos.

HealingMaps Take: InnerMost represents the cutting edge of ketamine therapy in Manhattan. Co-founded by Dr. Casey Paleos — a board-certified psychiatrist with over 12 years of clinical and research experience in psychedelic medicine — the clinic combines ketamine treatment with trauma-informed psychotherapy modalities like IFS, AEDP, and Gestalt. InnerMost also runs clinical research trials and trains therapists, making it one of the most academically rigorous ketamine programs in NYC.

Market Position: InnerMost is a Spravato-certified clinic in the City metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.

InnerMost Ketamine Cost Calculator

Ketamine Protocols Compared — What’s Offered at InnerMost

Industry pricing reference. InnerMost’s posted price: Initial session $300; standard visit $600. Contact the clinic for any package or sliding-scale options. The calculator above shows metro-level cost estimates across protocols.

What to Expect at Your First InnerMost Appointment

1. Initial intake call — Insurance verification, prior authorization workflow (Spravato requires documentation of failure on at least two antidepressant trials), and clinical eligibility check. Call (917) 336-2608 to schedule. InnerMost’s posted pricing: Initial session $300; standard visit $600.
2. Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the InnerMost clinical team.
3. First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at 137 E 25th St, 11th Floor, New York, NY 10010. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
4. Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.

What to Ask on Your InnerMost Consult Call

• How long has the InnerMost clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
• Walk me through InnerMost’s Spravato prior authorization process versus your IV ketamine cash-pay or superbill workflow — which is the better fit for my insurance situation?
• Which New York commercial insurers (Aetna, UnitedHealthcare, Empire BCBS, Oxford, Healthfirst) have you successfully obtained Spravato prior authorization through?
• Is the therapist who guides KAP sessions independently licensed, and how long are integration sessions after the dosing portion?
• What does InnerMost recommend for patients who don’t respond to the standard 6-session acute series?

Patient Questions about InnerMost

This 5-question summary is matched to the protocols and conditions InnerMost treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.

What ketamine protocols does InnerMost offer?

InnerMost offers Spravato, IV ketamine and KAP — a 3-protocol practice. Patients can switch between or combine modalities without changing providers. Confirm specific dosing schedules and which protocols are recommended for your condition during your consult.

Does InnerMost offer Spravato (esketamine)?

Yes — InnerMost offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.

Does InnerMost offer ketamine-assisted psychotherapy (KAP)?

Yes — InnerMost offers KAP, which combines ketamine dosing with structured psychotherapy during the dissociative window. KAP sessions are longer than standalone infusions and priced accordingly. A reasonable consult question: whether KAP is delivered by a single integrated provider, or by a separate therapist working with the prescribing clinician.

Is InnerMost suited for treatment-resistant depression?

InnerMost treats depression via Spravato (FDA-approved for TRD), IV ketamine (off-label, evidence-based), and KAP for trauma-anchored depression. The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.

Can InnerMost help with anxiety disorders?

Yes — InnerMost treats anxiety, including generalized anxiety, social anxiety, and panic disorder. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which of their protocols they typically recommend for anxiety-primary patients.

View all REMS-certified Spravato clinics in New York and across the United States.

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