Mass General Hospital IV Ketamine Clinic – Boston, Massachusetts Ketamine Clinics

✓ Last verified: April 22, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff

Known For: Harvard-affiliated academic medical center ketamine program — the gold standard in clinical research and evidence-based ketamine treatment.

💡 No clinic-specific pricing posted? See our ketamine therapy cost guide for typical pricing ranges by treatment type and insurance pathways.

HealingMaps Take: Mass General Hospital’s IV Ketamine Clinic represents the apex of evidence-based ketamine treatment in Boston — and arguably in the entire country. Led by Dr. Cristina Cusin, MD, the program operates within the research and clinical infrastructure of Massachusetts General Hospital, Harvard Medical School’s largest teaching hospital. This is not a standalone infusion clinic; it is an academic medical center program backed by decades of institutional expertise in psychiatry, anesthesiology, and clinical research. For patients who prioritize clinical rigor, safety infrastructure, and access to the latest research protocols, MGH is the definitive choice. The clinic offers both IV ketamine and intranasal esketamine, and the hospital setting provides a level of emergency response capability that no outpatient clinic can match.

Market Position: Mass General Hospital IV Ketamine Clinic is a Spravato-certified clinic in the Boston metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.

Mass General Hospital IV Ketamine Clinic Ketamine Cost Calculator

Ketamine Protocols Compared — What’s Offered at Mass General Hospital IV Ketamine Clinic

Industry pricing reference. Mass General Hospital IV Ketamine Clinic has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.

What to Expect at Your First Mass General Hospital IV Ketamine Clinic Appointment

1. Initial intake call — Insurance verification, prior authorization workflow (Spravato requires documentation of failure on at least two antidepressant trials), and clinical eligibility check. Call (617) 724-5510 to schedule.
2. Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Mass General Hospital IV Ketamine Clinic clinical team.
3. First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at Wang Building, Massachusetts General Hospital, Boston, MA 02114. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
4. Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.

What to Ask on Your Mass General Hospital IV Ketamine Clinic Consult Call

• How long has the Mass General Hospital IV Ketamine Clinic clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
• Walk me through Mass General Hospital IV Ketamine Clinic’s Spravato prior authorization process versus your IV ketamine cash-pay or superbill workflow — which is the better fit for my insurance situation?
• Have you worked with Tufts Health Plan, Harvard Pilgrim, BCBS Massachusetts, or Mass General Brigham insurance for Spravato prior authorization?
• Does Mass General Hospital IV Ketamine Clinic require a referral from a current treating psychiatrist, and how do you handle outside-prescriber medication-management coordination?
• What does Mass General Hospital IV Ketamine Clinic recommend for patients who don’t respond to the standard 6-session acute series?

Boston Ketamine Market Snapshot

Sources: CDC PLACES 2023 (Suffolk County, MA, crude prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.

• Adult depression in Suffolk County, MA: 22.5%
• Frequent mental distress (14+ days per month): 16.7%
• Adults lacking health insurance: 6.5%
• Suffolk County population: 785,443 · median household income $87,669
• Recent Boston-area inquiries to HealingMaps: A growing stream of Massachusetts residents have recently contacted us seeking ketamine care

Behind this data: HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,473 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.

From the 2026 Ketamine Industry Report

Even Spravato copays are HSA and FSA-eligible — meaning the $0–$250 per-session cost that commercial insurance leaves you can often be paid with pre-tax dollars, reducing the effective out-of-pocket by your marginal tax rate. Ask your Spravato-certified provider to document the treatment as medically necessary for your records. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.

Patient Questions about Mass General Hospital IV Ketamine Clinic

This 3-question summary is matched to the protocols and conditions Mass General Hospital IV Ketamine Clinic treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.

What ketamine protocols does Mass General Hospital IV Ketamine Clinic offer?

Mass General Hospital IV Ketamine Clinic offers Spravato and IV ketamine — a 2-protocol practice. Patients can switch between or combine modalities without changing providers. Confirm specific dosing schedules and which protocols are recommended for your condition during your consult.

Does Mass General Hospital IV Ketamine Clinic offer Spravato (esketamine)?

Yes — Mass General Hospital IV Ketamine Clinic offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.

Is Mass General Hospital IV Ketamine Clinic suited for treatment-resistant depression?

Mass General Hospital IV Ketamine Clinic treats depression via Spravato (FDA-approved for TRD), and IV ketamine (off-label, evidence-based). The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.

Learn more about the evidence behind ketamine for depression at the National Institute of Mental Health.

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