✓ Last verified: January 27, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff

Known For: Centrally located Union Square clinic offering insurance-covered Spravato and cutting-edge MindfulONE single-day TMS from a national depression care leader
| Google Reviews | 4.5 ★ |
| Location | San Francisco, CA (Union Square) |
| Address | San Francisco (Union Square area) |
| Phone | Contact via website |
| Website | mindfulhealthsolutions.com |
| Treatments | Spravato (Esketamine), TMS, MindfulONE TMS, Psychiatric Care |
| Conditions | Treatment-Resistant Depression, Anxiety, Mood Disorders |
| Cost | Spravato & TMS typically covered by insurance |
| Insurance | Most major insurance accepted |
| KAP Available | No (medically supervised Spravato) |
| Clinical Lead | Mindful Health Solutions Psychiatry Team |
HealingMaps Take: This Union Square location of Mindful Health Solutions offers the same high-caliber, insurance-covered Spravato treatment as their UCSF clinic, with the added convenience of a central downtown San Francisco location. As the second-largest Spravato administrator nationally, MHS brings significant clinical experience to each treatment. Ideal for patients who want proven, FDA-approved esketamine treatment with insurance coverage in a professional psychiatric setting.
Market Position: Mindful Health Solutions (Union Square) is a Spravato-certified clinic in the Francisco metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.
⚠ FDA-cleared indications for TMS therapy: treatment-resistant major depressive disorder (MDD), obsessive-compulsive disorder (OCD, Deep TMS only), anxious depression, short-term smoking cessation, and adolescent MDD (ages 15–21). Use of TMS for other conditions including PTSD, bipolar depression, fibromyalgia, and other indications is off-label — not currently FDA-cleared for those specific indications. Discuss your condition with the clinic to understand insurance coverage and clinical evidence.
Industry pricing reference. Mindful Health Solutions (Union Square)’s posted price: Spravato & TMS typically covered by insurance. Contact the clinic for any package or sliding-scale options. The calculator above shows metro-level cost estimates across protocols.
| Protocol | Typical Industry Cost | Offered Here |
|---|---|---|
| IV Ketamine | $350–$650/session | — |
| Spravato (esketamine) | $0–$250 copay (insured) | ✓ Yes |
| IM Ketamine | $250–$400/injection | — |
| KAP (with therapist) | $400–$1,200/session | — |
| At-home troches | $150–$300/month | — |
This 3-question summary is matched to the protocols and conditions Mindful Health Solutions (Union Square) treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
Yes — Mindful Health Solutions (Union Square) offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.
Mindful Health Solutions (Union Square) treats depression via Spravato (FDA-approved for TRD). The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.
Yes — Mindful Health Solutions (Union Square) treats anxiety, including generalized anxiety, social anxiety, and panic disorder. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which of their protocols they typically recommend for anxiety-primary patients.
This clinic offers TMS therapy as a third FDA-cleared treatment option (alongside ketamine and Spravato) for patients with treatment-resistant depression. Patients drive themselves to and from sessions, return to work the same day, and need no chaperone or recovery period. This clinic uses BrainsWay Deep TMS, the only TMS device with standalone FDA clearance for OCD via the H7 coil. Read our complete guide to TMS therapy for FDA-cleared conditions, device differences, insurance coverage by carrier, and what to expect at your first appointment. Browse verified TMS clinics in our directory.
View all REMS-certified Spravato clinics in California and across the United States.
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