South Dakota Ketamine Clinic – Sioux Falls, South Dakota Ketamine Clinics

Known For: Affordable pricing at $500 per session with free consultations. Calm, private treatment environment in South Dakota’s largest city.

HealingMaps Take: South Dakota Ketamine Clinic brings accessible, affordably priced ketamine infusion therapy to the upper Midwest. At $500 per infusion, the clinic sits at the lower end of the national pricing spectrum — a significant advantage in a state where many patients would otherwise need to travel to Minneapolis or Denver for treatment. The clinic also offers free consultations, eliminating the financial barrier to simply exploring whether ketamine therapy is right for you. Located on South Western Avenue in Sioux Falls — the state’s largest metro — the practice serves not only local patients but also draws from surrounding communities across eastern South Dakota, southwestern Minnesota, and northwestern Iowa. The addition of IV vitamin and fluid hydration add-ons suggests a practice that thinks holistically about patient wellness during the infusion experience. For patients in the Sioux Falls corridor seeking straightforward, no-frills ketamine treatment at a transparent price point, this is the most accessible option in the region.

Patient Review

“Ketamine therapy changed my life. The staff was compassionate and the environment felt safe and private. At $500 per session, it was more affordable than I expected for treatment that actually worked.”

About South Dakota Ketamine Clinic

South Dakota Ketamine Clinic is an IV ketamine infusion practice located at 6330 S Western Ave #120 in Sioux Falls, South Dakota. The clinic specializes in ketamine infusion therapy for depression, bipolar disorder, PTSD, anxiety, chronic pain, and CRPS. Each infusion is priced at $500, and the clinic offers free consultations for prospective patients. Optional IV vitamin and fluid hydration add-ons are available. The practice accepts HSA payments and works with CareCredit and Meeko Health for financing. Some insurance companies may reimburse for treatment.

For more on how ketamine therapy works, see our complete guide to ketamine therapy.

What People Like

Transparent, competitive pricing at $500 per infusion — among the most affordable in the region. Free consultations remove the financial risk of exploring treatment. The Sioux Falls location serves the largest metro area in South Dakota. HSA acceptance and financing through CareCredit and Meeko Health provide multiple payment pathways. IV vitamin and hydration add-ons enhance the treatment experience.

What People Don’t Like

The clinic does not offer Spravato, KAP, or TMS — IV ketamine infusions only. Specific provider credentials are not prominently listed on the website. Insurance coverage is not guaranteed — patients may need to submit for reimbursement after treatment. As a standalone ketamine clinic, there are no integrated psychiatric or therapy services on-site.

Getting Started at South Dakota Ketamine Clinic

Call (970) 219-1704 or visit sdketamine.com to schedule a free consultation. The clinic is located at 6330 S Western Ave #120, Sioux Falls, SD 57108. HSA is accepted, and CareCredit and Meeko Health financing are available.

Learn more about the evidence behind ketamine for depression at the National Institute of Mental Health.

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