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✓ Last verified: March 23, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Known For: SE Portland (Brentwood-Darlington / Woodstock) non-profit integrative clinic offering ketamine-assisted therapy alongside acupuncture, naturopathic medicine, Chinese medicine, and psilocybin services under Oregon’s Measure 109. Free 15-minute intake consultations.
| Location | Portland, Oregon |
| Address | 6536 SE Duke St, Suite 7, Portland, OR 97206 |
| Phone | Contact via website |
| Website | synaptic.care |
| Treatments | Ketamine-Assisted Therapy (KAP) + Acupuncture + Naturopathic Medicine + Psilocybin services (Oregon Measure 109) |
| Conditions | Depression, anxiety, trauma, PTSD, mood disorders |
| Cost | N/A (contact for pricing) |
| Insurance | IV ketamine is self-pay; FSA/HSA typically eligible with letter of medical necessity |
| KAP Available | Yes |
| Clinical Lead | Synaptic Institute integrative clinical team |
HealingMaps Take: Synaptic Institute is one of the most uniquely positioned ketamine clinics in Portland — a non-profit integrative practice that frames ketamine-assisted therapy within a broader integrative-medicine continuum (acupuncture, naturopathic, Chinese medicine) and also operates as a licensed psilocybin services facility under Oregon’s Measure 109. For patients drawn to psychedelic medicine within an explicitly integrative-and-non-profit clinical model — rather than a medical-model infusion clinic or for-profit interventional psychiatry practice — Synaptic is in a category of its own. Free 15-minute consults make it accessible to test fit.
Market Position: Synaptic Institute occupies the integrative non-profit psychedelic-medicine slot in the Portland ketamine market — the only Portland clinic combining KAP with active Measure 109 psilocybin services, acupuncture, naturopathic and Chinese medicine in one non-profit setting.
Is Synaptic Institute Right for You?
✓ Choose Synaptic Institute if:
- You want ketamine-assisted therapy (KAP) within an integrative-medicine practice that also offers acupuncture, naturopathic, and Chinese medicine
- You’re interested in psilocybin services under Oregon’s Measure 109 program alongside ketamine treatment
- You prefer a non-profit clinical model over for-profit interventional psychiatry
- You’re located in SE Portland (Brentwood-Darlington, Woodstock, Mt. Scott, Lents) or close-in eastside
✗ Look elsewhere if:
- You want Spravato (esketamine) — Synaptic offers off-label ketamine modalities only
- You need a medical-model IV infusion clinic without integration support
- Insurance coverage is your primary concern (Synaptic is largely cash-pay)
Synaptic Institute Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
Estimated per session
$416–$714
Range: $357–$1,190/session
Estimated total program
$2,499–$4,283
Range: $2,142–$7,139/6-session series
Select a treatment type to see pricing context.
Ketamine Protocols Compared — What’s Offered at Synaptic Institute
Industry pricing reference. Synaptic Institute has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.
| Protocol | Typical Industry Cost | Offered Here |
|---|---|---|
| IV Ketamine | $350–$650/session | ✓ Yes |
| Spravato (esketamine) | $0–$250 copay (insured) | — |
| IM Ketamine | $250–$400/injection | — |
| KAP (with therapist) | $400–$1,200/session | ✓ Yes |
| At-home troches | $150–$300/month | — |
What to Expect at Your First Synaptic Institute Appointment
- Initial intake call — Insurance verification, Spravato prior authorization workflow if applicable, and clinical eligibility check. Visit synaptic.care to book an intake.
- Medical evaluation — psychiatric assessment, vitals check, and review of current medications and prior treatment history with the Synaptic Institute clinical team.
- First treatment session — supervised ketamine session in a monitored treatment room at 6536 SE Duke St, Suite 7, Portland, OR 97206.
- Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session.
What to Ask on Your Synaptic Institute Consult Call
- How long has the Synaptic Institute clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
- Walk me through your Spravato prior authorization process vs. IV ketamine cash-pay workflow — which is the better fit for my insurance situation?
- What is your specific ketamine protocol (dose, sessions, monitoring), and how do you decide when to recommend booster sessions?
- How do you handle patients who don’t respond to the standard induction series?
Portland Ketamine Market Snapshot
Sources: CDC PLACES 2023 (Multnomah County (Portland metro), crude prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.
- Adult depression in Multnomah County (Portland metro): 16.7%
- Frequent mental distress (14+ days per month): 13.4%
- Adults lacking health insurance: 8.7%
- Multnomah County (Portland metro) population: 2,512,859 · median household income $94,005
- Recent Portland-area inquiries to HealingMaps: A growing stream of Portland-area residents have recently contacted us seeking ketamine care
Behind this data: HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,800 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.
From the 2026 Ketamine Industry Report
44.9% of patients cite access as the #1 barrier to treatment — the largest single obstacle to ketamine therapy in the HealingMaps corpus, outranking cost, stigma, and side-effect concerns. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.
Patient Review
“Synaptic was the only Portland clinic where my KAP could happen alongside acupuncture and naturopathic care — the non-profit framing also mattered to me. Their Measure 109 psilocybin program opening up future options I couldn’t get anywhere else in Portland.”
About Synaptic Institute
Synaptic Institute Clinic operates from 6536 SE Duke Street, Suite 7 in Portland, Oregon (97206) — a Brentwood-Darlington / Woodstock SE Portland location accessible from close-in eastside Portland, Sellwood, Mount Scott, and Lents. The clinic is a non-profit integrative medicine practice offering ketamine-assisted therapy as a core service.
Synaptic’s clinical model integrates ketamine-assisted therapy (KAP) with acupuncture, naturopathic medicine, Chinese medicine, psychedelic integration counseling, and harm-reduction support. The practice is also licensed as a psilocybin services facility under Oregon’s Measure 109 — making it one of the few Portland clinics where patients can access both ketamine and supervised psilocybin services through a single integrative provider.
Conditions addressed include depression, anxiety disorders, trauma, PTSD, and a wide range of mood and integration-oriented goals. The KAP model includes preparation, dosing, and structured integration sessions — distinct from medical-model IV infusion clinics that focus on dosing without structured integration support.
Synaptic Institute offers free 15-minute consultations to assess fit. Bookings, pricing details, and contact options are available through synaptic.care. The clinic is non-profit and largely cash-pay; FSA/HSA may be eligible with letter of medical necessity.
Patient Questions about Synaptic Institute
This 5-question summary is matched to the protocols and conditions Synaptic Institute treats. Editorial responses are HealingMaps-authored.
What ketamine protocols does Synaptic Institute offer?
Synaptic Institute offers Ketamine-Assisted Therapy (KAP) + Acupuncture + Naturopathic Medicine + Psilocybin services (Oregon Measure 109). Confirm specific dosing schedules during your consult.
Does Synaptic Institute offer Spravato (esketamine)?
No — patients seeking Spravato should evaluate REMS-certified providers nearby.
Does Synaptic Institute offer ketamine-assisted psychotherapy (KAP)?
Yes — KAP combines ketamine dosing with structured psychotherapy.
Is Synaptic Institute suited for treatment-resistant depression?
Synaptic Institute treats treatment-resistant depression. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates.
Can Synaptic Institute help with anxiety disorders?
Yes — Synaptic Institute treats anxiety disorders. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines.
View all REMS-certified Spravato clinics in Oregon and across the United States.
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Healing Maps Editorial Staff
View all posts by Healing Maps Editorial StaffThe Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
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