Dr. Sambunaris and Associates – Alpharetta, Georgia Ketamine Clinics, Spravato Clinics

✓ Last verified: April 21, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff

Known For: Dr. Angelo Sambunaris brings over 35 years of psychiatric experience and national recognition in anxiety and depression treatment to his Alpharetta practice. The clinic is one of the few in the Atlanta metro area offering multiple ketamine delivery methods—IV infusions, intramuscular injections, and Spravato (esketamine)—giving patients flexibility in their treatment approach. The standard protocol involves six infusions over two to three weeks with maintenance as needed.

HealingMaps Take: Dr. Sambunaris’ practice stands out for offering three distinct ketamine delivery methods—IV, intramuscular, and Spravato—allowing treatment to be tailored to each patient’s needs and preferences. His decades of clinical experience and research background in anxiety and depression provide a strong foundation for ketamine therapy. Reviews are mixed, with long-term patients praising the caring, non-judgmental environment while some newer patients have noted aggressive upselling. Prospective patients should ask detailed questions about costs and treatment plans during the initial consultation.

Market Position: Dr. Sambunaris and Associates is a Spravato-certified clinic in the Alpharetta metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.

Dr. Sambunaris and Associates Ketamine Cost Calculator

Ketamine Protocols Compared — What’s Offered at Dr. Sambunaris and Associates

Industry pricing reference. Dr. Sambunaris and Associates has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.

What to Expect at Your First Dr. Sambunaris and Associates Appointment

1. Initial intake call — Insurance verification, prior authorization workflow (Spravato requires documentation of failure on at least two antidepressant trials), and clinical eligibility check. Call (770) 817-9200 to schedule.
2. Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Dr. Sambunaris and Associates clinical team.
3. First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at 5755 North Point Parkway, Suite 256, Alpharetta, GA 30022. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
4. Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.

What to Ask on Your Dr. Sambunaris and Associates Consult Call

• How long has the Dr. Sambunaris and Associates clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
• Walk me through Dr. Sambunaris and Associates’s Spravato prior authorization process versus your IV ketamine cash-pay or superbill workflow — which is the better fit for my insurance situation?
• Are you in-network with BCBS Georgia, Aetna, or UnitedHealthcare for Spravato, or do you submit out-of-network and superbill?
• What does Dr. Sambunaris and Associates recommend for patients who don’t respond to the standard 6-session acute series?

Patient Questions about Dr. Sambunaris and Associates

This 5-question summary is matched to the protocols and conditions Dr. Sambunaris and Associates treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.

What ketamine protocols does Dr. Sambunaris and Associates offer?

Dr. Sambunaris and Associates offers Spravato, IV ketamine and IM ketamine — a 3-protocol practice. Patients can switch between or combine modalities without changing providers. Confirm specific dosing schedules and which protocols are recommended for your condition during your consult.

Does Dr. Sambunaris and Associates offer Spravato (esketamine)?

Yes — Dr. Sambunaris and Associates offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.

Is Dr. Sambunaris and Associates suited for treatment-resistant depression?

Dr. Sambunaris and Associates treats depression via Spravato (FDA-approved for TRD), and IV ketamine (off-label, evidence-based). The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.

Does Dr. Sambunaris and Associates treat PTSD?

Yes — Dr. Sambunaris and Associates treats PTSD. Both Spravato and IV ketamine can be used for trauma. Ketamine for trauma differs from depression treatment: dosing is often lower per session, and pairing the protocol with trauma-focused therapy between sessions is common. A reasonable consult question: whether PTSD patients here typically use ketamine alone or alongside an outside therapist.

Can Dr. Sambunaris and Associates help with anxiety disorders?

Yes — Dr. Sambunaris and Associates treats anxiety, including generalized anxiety, social anxiety, and panic disorder. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which of their protocols they typically recommend for anxiety-primary patients.

View all REMS-certified Spravato clinics across the United States.

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