✓ Last verified: April 9, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Known For: Kentuckiana Integrative Medicine, led by Dr. Rafael Cruz with over 25 years of clinical experience, offers IV ketamine infusion therapy alongside regenerative and integrative medicine services. Serving the Louisville metro from just across the river in Jeffersonville, Indiana, the clinic reports dramatic results with zero serious adverse effects over five years of ketamine administration.
Google Reviews
⭐ Highly rated
Location
Jeffersonville, Indiana
Address
405 East Court Ave, Suite 101, Jeffersonville, IN 47130
Phone
Contact clinic
Website
Contact clinic for website
Treatments
IV Ketamine Infusions, Regenerative Medicine, Integrative Therapies
HealingMaps Take: Dr. Cruz’s 25+ years of clinical experience and the clinic’s spotless safety record over five years of ketamine administration inspire confidence. Patients highlight the comfortable treatment environment—heated recliners, blankets, private bathrooms—and Dr. Cruz’s hands-on approach to teaching coping skills alongside infusions. A strong choice for Louisville-area patients seeking ketamine therapy with an integrative medicine framework.
Market Position: Kentuckiana Integrative Medicine is an IV-ketamine-focused clinic in the metro — the most common cash-pay protocol in the HealingMaps verified directory.
Is Kentuckiana Integrative Medicine Right for You?
✓ Choose Kentuckiana Integrative Medicine if:
You want supervised IV ketamine with real-time medical monitoring
You’re treating co-occurring depression and PTSD
✗ Look elsewhere if:
You need Spravato (FDA-approved esketamine) covered by your insurance
You want ketamine-assisted psychotherapy (KAP) with integrated talk therapy
Ketamine Protocols Compared — What’s Offered at Kentuckiana Integrative Medicine
Industry pricing reference. Kentuckiana Integrative Medicine has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.
Protocol
Typical Industry Cost
Offered Here
IV Ketamine
$350–$650/session
✓ Yes
Spravato (esketamine)
$0–$250 copay (insured)
—
IM Ketamine
$250–$400/injection
—
KAP (with therapist)
$400–$1,200/session
—
At-home troches
$150–$300/month
—
What to Expect at Your First Kentuckiana Integrative Medicine Appointment
Initial intake call — Brief medical history review, depression and anxiety screening, and medical clearance for IV ketamine. Schedule via Contact clinic for website.
Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Kentuckiana Integrative Medicine clinical team.
First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at 405 East Court Ave, Suite 101, Jeffersonville, IN 47130. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.
What to Ask on Your Kentuckiana Integrative Medicine Consult Call
How long has the Kentuckiana Integrative Medicine clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
Does Kentuckiana Integrative Medicine provide a superbill for out-of-network insurance reimbursement, and what’s a typical 6-session total cost including any follow-up?
What does Kentuckiana Integrative Medicine recommend for patients who don’t respond to the standard 6-session acute series?
Ketamine Market Snapshot
Sources: CDC PLACES 2023 (Clark County, , crude prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.
Adult depression in Clark County, : 26.5%
Frequent mental distress (14+ days per month): 18.2%
Adults lacking health insurance: 8.5%
Clark County population: 121,484 · median household income $69,005
Recent -area inquiries to HealingMaps: A growing stream of residents have recently contacted us seeking ketamine care
Behind this data:HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,473 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.
From the 2026 Ketamine Industry Report
For patients whose HSA or FSA funds are insufficient, third-party medical financing programs like CareCredit are accepted at a growing share of ketamine clinics — typically offering 6 to 24-month deferred-interest plans on the full acute-series cost of $2,100–$3,000. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.
Patient Review
“I did 6 sessions of ketamine infusion with dramatic results—I am now living life in color. Dr. Cruz taught me new coping skills which have been extremely helpful. The staff really care.” — Kentuckiana Integrative Medicine Patient
Testimonials from Kentuckiana Integrative Medicine Patients
“Ketamine Therapy saved me after years of depression and not getting help from countless antidepressants. Now I am finally happy and have found a great IT job.”
K. Perkins
Ketamine Therapy is truly a lifesaver. I was suicidal. Marriage in trouble. Now I am pleased with life, marriage and work and just finished nursing medical school.
Kentuckiana Integrative Medicine, with a main clinic in Jeffersonville, Indiana, provides ketamine infusion therapy to the Indiana and Kentucky regions. Recent research at leading universities shows ketamine to be a powerful medicine. It has changed how people with resistant pain and mental health conditions approach healing and growth. As a result, the staff at the Kentuckiana clinic offers this treatment for those suffering from conditions ranging from depression and bipolar disorder to CRPS and fibromyalgia.
Ketamine infusion therapy has benefits for a wide variety of sufferers. Those seeking this powerful treatment suffer from conditions called “refractory”, or “resistant”. Such conditions have not responded positively to mainstream treatments and therapies. Of those who undergo this treatment, 70-80 percent report significant positive results.
Kentuckiana Ketamine Institute is one the most experienced Ketamine Treatment centers in Kentuckiana and the country. There is no other anti-suicidal and antidepressant therapy that is as fast, accessible and as effective as Ketamine Therapy. Many patients see improvement even after the first treatment. Six treatments within 2-3 weeks are required for best results and occasionally “booster” treatments. Over seven years ago, Kentuckiana introduced Ketamine to the community for mental health challenges such as Treatment Resistant Depression, Postpartum Depression, Reactive Depression, Bipolar Disorder, PTSD, OCD, Severe Anxiety and Pain Issues [Fibromyalgia, Neuropathy, Migraines Multiple Sclerosis] with tremendous success.
A Recognized Leader
Dr. Rafael F. Cruz, M.D. runs Kentuckiana Integrative Medicine. A recognized leader in integrative practices, Dr. Cruz combines cutting-edge research with non-mainstream practices. The resulting combination leads to a personally-tailored treatment plan for every visitor to the clinic. In fact, the holistic practice of Dr. Cruz is reflected in the compassionate and understanding staff at Kentuckiana. Sufferers will find a welcome and comfortable environment in which to heal.
Dr. Cruz has over 25 years of clinical experience in Emergency Medicine, Anesthesia and Integrative Medicine and is extremely experienced in the safe use of Ketamine therapy. Over 30 years ago, he personally experienced the devastating effects of depression so he can relate well to his patients. Kentuckiana Integrative Medicine treats individuals with listed conditions as young as 12 years old, something few clinics are available to do.
Mainstream treatment is successful for a wide range of pain and mental health conditions. With this in mind, for conditions that continue to resist oral medications and physical therapies, ketamine infusion offers a fast and effective avenue. The experts at Kentuckiana Integrative Medicine will guide you with expertise and gentleness into a new lease on life.
You will be treated with the compassion and respect you deserve in a clean private room with a spa like environment including Lazy boy chair with heat, massage, blanket and more. You will learn lifelong techniques and strategies that will dramatically enhance your potential for success. Experience the difference at Kentuckiana Ketamine Institute, where your improvement is the clinic’s most important mission.
Offered Treatments
Kentuckiana Integrative Medicine primarily utilizes IV Intravenous and IM Intramuscular Ketamine therapy. However, Nasal Spravato Ketamine is offered for adults with Medicare or commercial insurance when coverage is available. Nasal Spravato Ketamine is only approved for treatment resistant depression in patients who have tried and failed to improve with at least 2-3 anti-depressants or ECT or TCM therapies.
Kentuckiana Integrative Medicine currently cannot accept Medicaid insurances.
IV Ketamine Infusion Therapy
Spravato ketamine nasal spray
Ketamine therapy can help patients with a variety of conditions:
Neuropathic Pain
Trigeminal Neuralgia
CRPS (Complex Regional Pain Syndrome)
RSD (Reflex Sympathetic Dystrophy)
Phantom Limb pain
Diabetic pain
Post-herpetic Neuralgia
Chronic back and neck pain
Fibromyalgia
Debilitating Musculoskeletal and Joint Pain
Migraines
PTSD (Post Traumatic Stress Disorder)
OCD (Obsessive Compulsive Disorder)
Suicidal Thinking
Treatment Resistant Depression
Bipolar Disorder
Reactive Depression
Postpartum Depression
Addictions
Severe Anxiety
Cost of Treatment
Consult – $300
Treatment – $2,500-$6,000 for seven treatments of Ketamine
The higher costs listed are if other services are desired such as IV Vitamin therapy which is indicated when there is a history of severe fatigue, fibromyalgia, recurrent infections, etc.
Your Treatment: What to Expect
An initial assessment is necessary to rule out potential contraindications. Patients undergo a series of infusions over 1-2 weeks. Although a psychedelic compound, ketamine is infused in small enough amounts that side effects are subtle, and often quite pleasurable. First infusions at Kentuckiana Integrative Medicine are at a lower dose. Upon establishing tolerance to the medication, subsequent infusions are stronger and longer.
Ketamine is an effective medicine for most who come to it. However, approximately 20 percent of patients do not respond positively to the medication. Positive results cannot be guaranteed.
Ketamine therapy is not the first stop on the road to treating pain and mental health issues. Those who come to Kentuckiana Integrative Medicine will have tried other medications and therapies first. Once a condition is considered to be “resistant”, clinical trials with ketamine infusion show a 70-80 percent success rate. Kentuckiana Integrative Medicine can offer hope, healing, and growth.
FREE Private Self Assessment Tools: You can Kentuckiana Integrative Medicine’s self-assessment tools and complete your Medical History Intake Form for more information.
Patient Questions about Kentuckiana Integrative Medicine
This 3-question summary is matched to the protocols and conditions Kentuckiana Integrative Medicine treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
Is Kentuckiana Integrative Medicine suited for treatment-resistant depression?
Kentuckiana Integrative Medicine treats depression via IV ketamine (off-label, evidence-based). Insurance coverage is rare for IV/KAP — most patients pay out of pocket. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.
Does Kentuckiana Integrative Medicine treat chronic pain conditions?
Yes — Kentuckiana Integrative Medicine treats chronic pain. They use IV ketamine for pain, which typically means longer infusion times and higher cumulative doses than mental-health protocols. Common indications include complex regional pain syndrome (CRPS), fibromyalgia, and certain neuropathic pain syndromes. Pain pricing varies significantly by structure: per-infusion vs. multi-day inpatient packages — verify how this clinic structures their billing.
Does Kentuckiana Integrative Medicine treat PTSD?
Yes — Kentuckiana Integrative Medicine treats PTSD. Ketamine for trauma differs from depression treatment: dosing is often lower per session, and pairing the protocol with trauma-focused therapy between sessions is common. A reasonable consult question: whether PTSD patients here typically use ketamine alone or alongside an outside therapist.
Excellent Facility with knowledgeable and compassionate team that are dedicated to helping patients with pain and mental health challenges. Ketamine genuinely save my life bringing back joy and function. I cannot thank you enough.
Karen Louisville, KY
The Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
Karen A Sherlock
August 26, 2022 at 10:00 pmExcellent Facility with knowledgeable and compassionate team that are dedicated to helping patients with pain and mental health challenges. Ketamine genuinely save my life bringing back joy and function. I cannot thank you enough.
Helpful ReviewKaren Louisville, KY