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✓ Edited by Angelica Bottaro for HealingMaps Editorial Staff
Known For: South County’s in-office Spravato program inside a full behavioral-health practice — psychiatry, therapy, TMS, and intensive outpatient programming under one organization, with a second office in West County and more than 20 years serving the St. Louis metro (formerly Serenity Health, LLC).
| Location | St. Louis, Missouri |
| Address | 5000 Cedar Plaza Pkwy, Suite 320, St. Louis, MO 63128 |
| Phone | (314) 200-1366 |
| Website | onebehavioralmo.com |
| Treatments | Spravato (Esketamine, REMS-certified) + TMS Therapy + Psychiatry, Therapy & Intensive Outpatient Programs |
| Conditions | Treatment-resistant depression, major depressive disorder, anxiety, and co-occurring behavioral health conditions |
| Cost | N/A (contact for pricing) |
| Insurance | Spravato typically insurance-billed across most major plans |
| KAP Available | No |
| Clinical Lead | One Behavioral Missouri psychiatric team (formerly Serenity Health, LLC; 20+ years serving the St. Louis metro) |
HealingMaps Take: One Behavioral gives South County what the Spravato map otherwise leaves to central and west county: REMS-certified esketamine inside an established behavioral-health system rather than a standalone clinic. The practice — Serenity Health, LLC until its rebrand — pairs Spravato with TMS, psychiatry, therapy, and IOP-level care, so patients with more complex needs stay inside one organization. The Cedar Plaza office anchors South County with a second location on Old Ballas Road in West County.
Market Position: One Behavioral occupies the full-continuum behavioral-health slot in the South County market — Spravato plus TMS within a practice that also runs therapy and intensive outpatient programs, differentiated by two decades of metro history and two county locations.
Is One Behavioral Right for You?
✓ Choose One Behavioral if:
- You want insurance-billed Spravato inside a full psychiatric practice
- You may need more than medication — therapy and IOP run in the same organization
- You’re in South County, Oakville, Mehlville, Concord, or Fenton
- The West County office (11709 Old Ballas Rd, Suite 105) is more convenient — same practice
- You value a program with 20+ years of St. Louis history behind it
✗ Look elsewhere if:
- You want IV or IM ketamine — One Behavioral’s ketamine-class option is Spravato
- You’re seeking ketamine-assisted psychotherapy
- You’re searching under their former name Serenity Health — same practice, new name
One Behavioral Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
Estimated per session
$416–$714
Range: $357–$1,190/session
Estimated total program
$2,499–$4,283
Range: $2,142–$7,139/6-session series
Select a treatment type to see pricing context.
Ketamine Protocols Compared — What’s Offered at One Behavioral
Industry pricing reference. One Behavioral has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.
| Protocol | Typical Industry Cost | Offered Here |
|---|---|---|
| IV Ketamine | $350–$650/session | — |
| Spravato (esketamine) | $0–$250 copay (insured) | ✓ Yes |
| IM Ketamine | $250–$400/injection | — |
| KAP (with therapist) | $400–$1,200/session | — |
| At-home troches | $150–$300/month | — |
What to Expect at Your First One Behavioral Appointment
- Initial intake call — Insurance verification, Spravato prior authorization workflow if applicable, and clinical eligibility check. Call (314) 200-1366 to schedule.
- Medical evaluation — psychiatric assessment, vitals check, and review of current medications and prior treatment history with the One Behavioral clinical team.
- First treatment session — supervised ketamine session in a monitored treatment room at 5000 Cedar Plaza Pkwy, Suite 320, St. Louis, MO 63128.
- Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session.
What to Ask on Your One Behavioral Consult Call
- How long has the One Behavioral clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
- Walk me through your Spravato prior authorization process vs. TMS coverage pathway — which is the better fit for my insurance situation?
- What is your specific ketamine protocol (dose, sessions, monitoring), and how do you decide when to recommend booster sessions?
- How do you handle patients who don’t respond to the standard induction series?
St. Louis Ketamine Market Snapshot
Sources: CDC PLACES 2023 (St. Louis County (South County — Cedar Plaza), crude prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.
- Adult depression in St. Louis County (South County — Cedar Plaza): 16.7%
- Frequent mental distress (14+ days per month): 13.4%
- Adults lacking health insurance: 8.7%
- St. Louis County (South County — Cedar Plaza) population: 2,820,000 · median household income $75,000
- Recent St. Louis-area inquiries to HealingMaps: A growing stream of St. Louis-area residents have recently contacted us seeking ketamine care
Behind this data: HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,800 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.
From the 2026 Ketamine Industry Report
44.9% of patients cite access as the #1 barrier to treatment — the largest single obstacle to ketamine therapy in the HealingMaps corpus, outranking cost, stigma, and side-effect concerns. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.
Patient Review
“When my depression needed more than monthly med checks, they stepped me up to their day program and started Spravato without sending me anywhere else. One chart, one team — that continuity is why it worked this time.”
About One Behavioral
One Behavioral Missouri — formerly Serenity Health, LLC — treats South County patients at 5000 Cedar Plaza Pkwy, Suite 320 (63128), with a second metro office at 11709 Old Ballas Rd, Suite 105 in West County and a Columbia, Missouri location beyond the metro. The practice has served the St. Louis area for more than 20 years.
Its interventional program centers on in-office Spravato (esketamine) for treatment-resistant depression, administered under the FDA REMS protocol with post-dose monitoring, alongside TMS therapy — both inside a practice that also provides psychiatric evaluation, medication management, individual therapy, and intensive outpatient programming.
Spravato and TMS are typically insurance-billable for qualifying diagnoses; coverage varies by plan. Conditions treated include treatment-resistant depression, major depressive disorder, anxiety, and co-occurring behavioral health conditions.
To schedule, call (314) 200-1366 or visit onebehavioralmo.com.
Patient Questions about One Behavioral
This 5-question summary is matched to the protocols and conditions One Behavioral treats. Editorial responses are HealingMaps-authored.
What ketamine protocols does One Behavioral offer?
One Behavioral offers Spravato (Esketamine, REMS-certified) + TMS Therapy + Psychiatry, Therapy & Intensive Outpatient Programs. Confirm specific dosing schedules during your consult.
Does One Behavioral offer Spravato (esketamine)?
Yes — One Behavioral offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose.
Does One Behavioral offer ketamine-assisted psychotherapy (KAP)?
One Behavioral operates a medical-model program. Patients seeking explicit KAP with a licensed integration therapist should evaluate practices that pair the dosing experience with structured therapy.
Is One Behavioral suited for treatment-resistant depression?
One Behavioral treats treatment-resistant depression. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates.
Can One Behavioral help with anxiety disorders?
Yes — One Behavioral treats anxiety disorders. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines.
View all REMS-certified Spravato clinics in Missouri and across the United States.
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Healing Maps Editorial Staff
View all posts by Healing Maps Editorial StaffThe Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
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