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✓ Last verified: February 23, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Known For: Cincinnati’s most holistic ketamine-assisted psychotherapy practice, integrating KAP with art therapy, acupuncture, Traditional Chinese Medicine, bodywork, and somatic practices — all under physician supervision with a 5.0 Google rating.
| Review Scores | 5.0 Google rating; patients praise the deeply integrative and holistic approach |
| Location | Cincinnati, OH |
| Address | 455 Delta Ave, Suite 303B, Cincinnati, OH 45226 |
| Phone | (513) 212-5482 |
| Website | oneheartmentalhealthcollab.com |
| Treatments | Ketamine-Assisted Psychotherapy (KAP), Spravato (Esketamine), Art Therapy, Bodywork, Somatic/Mindfulness Practices, Acupuncture, Traditional Chinese Medicine, Group Therapy, Nutrition Counseling |
| Conditions Treated | Treatment-Resistant Depression, Anxiety, PTSD, Trauma, Complex Mental Health Conditions |
| Cost | First KAP round $750 (includes intake, prep, medicine session, integration); additional rounds $550 each |
| Insurance | Cash/check/credit; superbills provided for out-of-network reimbursement |
| KAP Available? | Yes — physician and therapist present throughout every session |
| Clinical Lead | James Michael Weeks, MD — Board-Certified Internal Medicine, completed psychedelic facilitator training through SoundMind (Philadelphia) |
HealingMaps Take: One Heart Mental Health Collaborative is doing something genuinely different in the Cincinnati ketamine space. While most clinics offer infusions and maybe a therapy referral, One Heart builds an entire healing ecosystem around the ketamine experience — art therapy, bodywork, somatic practices, acupuncture, Traditional Chinese Medicine, nutrition counseling, and group integration circles. This is not a medical model with add-ons; it is a holistic healing model that uses ketamine as one catalyst among many. Dr. James Weeks brings a rare combination of credentials: board-certified in internal medicine (he understands the medical side) with year-long psychedelic facilitator training through SoundMind in Philadelphia (he understands the therapeutic side). Both a physician and a licensed therapist are present throughout every KAP session — a level of dual oversight that few clinics match. The pricing is transparent and competitive: $750 for the first round (which includes medical intake, preparation, the medicine session, and integration) and $550 for subsequent rounds. The 5.0 Google rating with consistent praise suggests this model is working. For patients who see their depression or trauma as a whole-person issue rather than a brain chemistry problem, One Heart is the most integrative option in the Cincinnati region.
Market Position: One Heart Mental Health Collaborative is a Spravato-certified clinic in the Cincinnati metro. Spravato (esketamine) is the FDA-approved ketamine treatment that most commercial insurance plans cover after prior authorization — unlike cash-pay IV ketamine.
Is One Heart Mental Health Collaborative Right for You?
✓ Choose One Heart Mental Health Collaborative if:
- You have commercial insurance and a documented treatment-resistant depression diagnosis (Spravato pathway)
- You’re seeking ketamine-assisted psychotherapy (KAP) with a licensed therapist alongside dosing
- You’re treating co-occurring depression and PTSD
✗ Look elsewhere if:
- You’re seeking cash-pay IV ketamine instead of insurance-billed Spravato
- You need same-week appointments — Spravato prior authorization typically takes 1–3 weeks
- You’re seeking ketamine for chronic pain (this clinic focuses on mental health)
One Heart Mental Health Collaborative Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
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Select a treatment type to see pricing context.
Ketamine Protocols Compared — What’s Offered at One Heart Mental Health Collaborative
Industry pricing reference. One Heart Mental Health Collaborative’s posted price: First KAP round $750 (includes intake, prep, medicine session, integration); additional rounds $550 each. Contact the clinic for any package or sliding-scale options. The calculator above shows metro-level cost estimates across protocols.
| Protocol | Typical Industry Cost | Offered Here |
|---|---|---|
| IV Ketamine | $350–$650/session | — |
| Spravato (esketamine) | $0–$250 copay (insured) | ✓ Yes |
| IM Ketamine | $250–$400/injection | — |
| KAP (with therapist) | $400–$1,200/session | ✓ Yes |
| At-home troches | $150–$300/month | — |
What to Expect at Your First One Heart Mental Health Collaborative Appointment
- Initial intake call — Insurance verification, prior authorization workflow (Spravato requires documentation of failure on at least two antidepressant trials), and clinical eligibility check. Call (513) 212-5482 to schedule. One Heart Mental Health Collaborative’s posted pricing: First KAP round $750 (includes intake, prep, medicine session, integration); additional rounds $550 each.
- Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the One Heart Mental Health Collaborative clinical team.
- First treatment session — supervised Spravato (intranasal esketamine) in a private treatment room, lasting approximately 90 minutes (40-minute session + 60 minutes monitoring). Sessions are held at 455 Delta Ave, Suite 303B, Cincinnati, OH 45226. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
- Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your Spravato session.
What to Ask on Your One Heart Mental Health Collaborative Consult Call
- How long has the One Heart Mental Health Collaborative clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
- How long does One Heart Mental Health Collaborative’s Spravato prior authorization typically take with my specific insurance plan, and what happens if it’s denied?
- Have you coordinated with Ohio’s major insurer networks (Anthem, UnitedHealthcare, Medical Mutual) for Spravato authorizations, and how long is your typical timeline?
- Is the therapist who guides KAP sessions independently licensed, and how long are integration sessions after the dosing portion?
- What does One Heart Mental Health Collaborative recommend for patients who don’t respond to the standard 6-session acute series?
Patient Questions about One Heart Mental Health Collaborative
This 5-question summary is matched to the protocols and conditions One Heart Mental Health Collaborative treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
What ketamine protocols does One Heart Mental Health Collaborative offer?
One Heart Mental Health Collaborative offers Spravato and KAP — a 2-protocol practice. Patients can switch between or combine modalities without changing providers. Confirm specific dosing schedules and which protocols are recommended for your condition during your consult.
Does One Heart Mental Health Collaborative offer Spravato (esketamine)?
Yes — One Heart Mental Health Collaborative offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose. Spravato is the primary insurance-covered ketamine option for treatment-resistant depression. Worth confirming the prior-authorization timeline before booking your first session.
Does One Heart Mental Health Collaborative offer ketamine-assisted psychotherapy (KAP)?
Yes — One Heart Mental Health Collaborative offers KAP, which combines ketamine dosing with structured psychotherapy during the dissociative window. KAP sessions are longer than standalone infusions and priced accordingly. A reasonable consult question: whether KAP is delivered by a single integrated provider, or by a separate therapist working with the prescribing clinician.
Is One Heart Mental Health Collaborative suited for treatment-resistant depression?
One Heart Mental Health Collaborative treats depression via Spravato (FDA-approved for TRD), and KAP for trauma-anchored depression. The Spravato pathway is the most likely to obtain commercial insurance coverage. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.
Can One Heart Mental Health Collaborative help with anxiety disorders?
Yes — One Heart Mental Health Collaborative treats anxiety, including generalized anxiety, social anxiety, and panic disorder. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which of their protocols they typically recommend for anxiety-primary patients.
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Healing Maps Editorial Staff
View all posts by Healing Maps Editorial StaffThe Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
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