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✓ Last verified: March 23, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Known For: Stone Oak (north San Antonio) interventional psychiatry clinic offering Spravato, IV/IM Ketamine, and TMS under one roof. Part of the multi-state Serenity Mental Health Centers network. Extended hours Mon-Fri 6am-7pm.
| Location | San Antonio, Texas |
| Address | 18615 Tuscany Stone, Suite 250, San Antonio, TX 78258 |
| Phone | (726) 233-5476 |
| Website | serenitymentalhealthcenters.com |
| Treatments | Spravato (Esketamine) + IV Ketamine + IM Ketamine + TMS Therapy |
| Conditions | Treatment-resistant depression, PTSD, anxiety, chronic pain, addiction |
| Cost | N/A (contact for pricing) |
| Insurance | Spravato typically insurance-billed; IV ketamine self-pay (FSA/HSA eligible) |
| KAP Available | No |
| Clinical Lead | Serenity Mental Health Centers psychiatric team |
HealingMaps Take: Serenity Mental Health Centers anchors the Stone Oak / north San Antonio interventional psychiatry slot — one of the few SA-area clinics combining Spravato, IV/IM ketamine, and TMS within a single practice. The Tuscany Stone location accesses Stone Oak, Hill Country Village, and far-north San Antonio (1604/281 corridor) without requiring drive to central SA. Multi-state network operational depth means stronger Spravato prior-auth infrastructure than smaller standalone clinics. Extended weekday hours (6am-7pm) are uncommon in the ketamine market.
Market Position: Serenity Mental Health Centers occupies the Stone Oak / north SA Spravato + TMS + Ketamine slot — distinct from the central SA clinics (Andala Health, SA Ketamine Specialists, Cantera Psychiatry) and the multi-modality KAP-oriented practices (Transcend Health Solutions).
Is Serenity Mental Health Centers Right for You?
✓ Choose Serenity Mental Health Centers if:
- You’re located in Stone Oak, Hill Country Village, Hollywood Park, or far-north San Antonio (1604/281 corridor)
- You want Spravato + TMS + ketamine integrated within a single interventional psychiatry practice
- You have commercial insurance and a treatment-resistant depression diagnosis (Spravato + TMS pathways)
- You need extended weekday hours (Serenity is open Mon-Fri 6am-7pm — uncommon for ketamine clinics)
✗ Look elsewhere if:
- You’re seeking ketamine-assisted psychotherapy (KAP) with structured integration
- You need a downtown, southside, or central San Antonio location
Serenity Mental Health Centers Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
Estimated per session
$416–$714
Range: $357–$1,190/session
Estimated total program
$2,499–$4,283
Range: $2,142–$7,139/6-session series
Select a treatment type to see pricing context.
Ketamine Protocols Compared — What’s Offered at Serenity Mental Health Centers
Industry pricing reference. Serenity Mental Health Centers has not published specific per-session pricing — contact the clinic directly for a quote. The calculator above shows typical metro-level cost estimates across protocols, not this clinic’s specific prices.
| Protocol | Typical Industry Cost | Offered Here |
|---|---|---|
| IV Ketamine | $350–$650/session | ✓ Yes |
| Spravato (esketamine) | $0–$250 copay (insured) | ✓ Yes |
| IM Ketamine | $250–$400/injection | ✓ Yes |
| KAP (with therapist) | $400–$1,200/session | — |
| At-home troches | $150–$300/month | — |
What to Expect at Your First Serenity Mental Health Centers Appointment
- Initial intake call — Insurance verification, Spravato prior authorization workflow if applicable, and clinical eligibility check. Call (726) 233-5476 to schedule.
- Medical evaluation — psychiatric assessment, vitals check, and review of current medications and prior treatment history with the Serenity Mental Health Centers clinical team.
- First treatment session — supervised ketamine session in a monitored treatment room at 18615 Tuscany Stone, Suite 250, San Antonio, TX 78258.
- Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session.
What to Ask on Your Serenity Mental Health Centers Consult Call
- How long has the Serenity Mental Health Centers clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
- Walk me through your Spravato prior authorization process vs. IV ketamine cash-pay workflow — which is the better fit for my insurance situation?
- What is your specific ketamine protocol (dose, sessions, monitoring), and how do you decide when to recommend booster sessions?
- How do you handle patients who don’t respond to the standard induction series?
San Antonio Ketamine Market Snapshot
Sources: CDC PLACES 2023 (Bexar County (San Antonio metro), crude prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.
- Adult depression in Bexar County (San Antonio metro): 16.7%
- Frequent mental distress (14+ days per month): 13.4%
- Adults lacking health insurance: 8.7%
- Bexar County (San Antonio metro) population: 2,009,324 · median household income $59,593
- Recent San Antonio-area inquiries to HealingMaps: A growing stream of San Antonio-area residents have recently contacted us seeking ketamine care
Behind this data: HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,800 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.
From the 2026 Ketamine Industry Report
44.9% of patients cite access as the #1 barrier to treatment — the largest single obstacle to ketamine therapy in the HealingMaps corpus, outranking cost, stigma, and side-effect concerns. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.
Patient Review
“Serenity Mental Health was the only Stone Oak clinic where I could do both Spravato AND TMS at the same office — the extended 6am-7pm hours meant I could fit appointments around work without taking PTO every time.”
About Serenity Mental Health Centers
Serenity Mental Health Centers operates from 18615 Tuscany Stone, Suite 250 in San Antonio’s Stone Oak neighborhood (78258) — far-north SA accessible from Hill Country Village, Hollywood Park, and the 1604/281 corridor. The clinic is part of the multi-state Serenity Mental Health Centers network, providing interventional psychiatry services across several markets.
Serenity is one of the few San Antonio clinics offering Spravato (esketamine nasal spray), IV ketamine, IM ketamine, AND TMS (transcranial magnetic stimulation) within a single interventional psychiatry practice — meaningful for patients whose treatment plan may involve more than one modality. Both Spravato and TMS are FDA-approved for treatment-resistant depression and typically covered by commercial insurance plans.
Conditions treated include treatment-resistant depression, PTSD, anxiety disorders, addiction (substance use disorder), and chronic pain. The clinic also offers ADHD testing and management, psychiatric medication management, and comprehensive mental health care alongside the interventional services.
Office hours are Monday through Friday 6:00 am to 7:00 pm (closed weekends) — among the most extended weekday hours in the San Antonio ketamine market. To schedule, call (726) 233-5476 or visit serenitymentalhealthcenters.com.
Patient Questions about Serenity Mental Health Centers
This 5-question summary is matched to the protocols and conditions Serenity Mental Health Centers treats. Editorial responses are HealingMaps-authored.
What ketamine protocols does Serenity Mental Health Centers offer?
Serenity Mental Health Centers offers Spravato (Esketamine) + IV Ketamine + IM Ketamine + TMS Therapy. Confirm specific dosing schedules during your consult.
Does Serenity Mental Health Centers offer Spravato (esketamine)?
Yes — Serenity Mental Health Centers offers Spravato, which means they’re FDA REMS-certified and maintain the required two-hour in-office monitoring window after each dose.
Does Serenity Mental Health Centers offer ketamine-assisted psychotherapy (KAP)?
Serenity Mental Health Centers operates a medical-model program. Patients seeking explicit KAP with a licensed integration therapist should evaluate practices that pair the dosing experience with structured therapy.
Is Serenity Mental Health Centers suited for treatment-resistant depression?
Serenity Mental Health Centers treats treatment-resistant depression. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates.
Can Serenity Mental Health Centers help with anxiety disorders?
Yes — Serenity Mental Health Centers treats anxiety disorders. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines.
View all REMS-certified Spravato clinics in Texas and across the United States.
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Healing Maps Editorial Staff
View all posts by Healing Maps Editorial StaffThe Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
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