How To Prepare For An Ayahuasca Experience
Last reviewed and updated: July 28, 2026.
Key Takeaways
| The MAOI risk | Ayahuasca acts as an MAO inhibitor, which makes combining it with SSRIs or other serotonergic drugs potentially life-threatening (serotonin syndrome). |
| Medication tapering | Contraindicated medications should be tapered well in advance under medical supervision, often several weeks, and never stopped abruptly alone. |
| Health screening | Reputable retreats screen out psychosis or bipolar history and certain cardiac conditions before accepting participants. |
| The dieta | Traditional preparation avoids alcohol, recreational drugs, certain foods, and sexual activity for a period before ceremony. |
| Vetting a retreat | Look for real medical screening, experienced facilitators, and emergency preparedness. Skipping screening is the biggest red flag. |
You feel the call. You’ve been receiving the signs. You know it’s time to drink ayahuasca. Maybe you’ve even chosen a retreat center, and now it’s time to get serious about preparation.
Choosing to drink ayahuasca is no small feat, and requires proper preparation, no matter how many psychedelics you may have taken in the past. Like with most sacred medicines, the more you put in, the more you get out–our relationships with these medicines should be reciprocal and putting in the effort to properly prepare indicates that.
In this guide, we describe essential ways to prepare for an ayahuasca retreat, delving into topics like intention-setting, integration, diet, lifestyle, and much more.
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Ayahuasca is Not a Recreational Experience
Firstly, don’t travel to Latin America and take ayahuasca as a fun, adventurous thing to do. Ayahuasca is not a recreational drug. It may provide you with intensely positive states of mind, but it does not give you an easy-going experience where you just see pretty patterns and laugh with others.
Often, ayahuasca offers people a profound psychedelic experience.
This can involve the following.
- Visions
- Confronting past trauma and difficult memories and emotions
- The feeling of traveling to other realms
- Communicating with entities, ancestors, or Nature.
- Mystical effects like coming in contact with “God”, ego death, interconnectedness, and losing the sense of space and time
- Feelings of happiness, joy, and lightness.
- Sinking into your body more deeply.
If you’re expecting a recreational experience from ayahuasca, just a wild ride, like some sort of psychedelic rollercoaster, you may indeed have a great time, but you may also find yourself unprepared for what actually occurs.
Understanding that the experience can be highly personal, profound, emotionally challenging, and even disturbing at times, will help you trust that everything you experience is normal.
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Ayahuasca is known to produce some noticeable physical effects like nausea, vomiting, and, in some instances, diarrhea. Actually, ayahuasca shamans and users of the brew do not consider vomiting a “side effect”, but, rather, an important part of the ceremony.
It is commonly referred to as purging or la purga. It is seen as a form of physical, psychological, and spiritual cleansing.
After drinking down the brew, you might feel some nausea within 20 minutes. This is normal. Not everyone vomits, but it is common to. You may feel a sudden urge to vomit and you may do so multiple times. It’s important to remember that this is the medicine doing its healing work and you will likely feel a lot lighter afterwards. And keep your bucket close, always!
In addition to vomiting, it’s not uncommon for ayahuasca to provoke other ways of emotional and energetic purging, including trembling/shaking, crying, laughing, yawning, sweating, talking, or the urge to stretch and move your body. These are also all normal and nothing to be ashamed about, and any good retreat center will have trained facilitators on hand to help you should they get very intense.
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The Ayahuasca Diet
Many shamans, retreat organizers, and ayahuasca users strongly believe in the importance of following the ayahuasca diet (or dieta) in the weeks and days prior to drinking the brew. This involves avoiding certain foods, beverages, and lifestyle habits (like sex and masturbation). The idea behind the diet is to enter into the experience as “clean” a vessel as possible so you can connect deeply with the medicine.
Kat Courtney, a trained ayahuasquera under the Shipibo lineage and CEO of Plant Medicine People, says “if you’re about to sit with ayahuasca, you just want to eat a clean diet. Very little salt, no sugar, no spice.”
Courtney also recommends avoiding red meat. “Reason being, first of all, they’re dense proteins. They’re hard to digest. Typically, they stay in the system for longer and density prevents the flow of energy of ayahuasca and makes it harder for her to work.”
In addition, it’s also advised to avoid dairy products, highly processed foods, fermented and/or aged foods, alcohol, cannabis, and any other synthetic street drugs.
The Reasons Behind the Dieta
Why do folks do this before they drink ayahuasca? “We’re removing all of these things, dense energies, things that keep us more tethered on a physical level so that we can set ourselves up for an easier, more graceful expansion into her energies,” explains Courtney. “What we’re doing with with plant medicines is connecting to subtle energy bodies.”
It’s important to see working with ayahuasca as a reciprocal relationships, says Courtney. “We get what we give. We are going to ayahuasca [and other medicines] with the biggest asks,” Courtney says. Recognize the gravity. “We are asking for profound healing and the secrets of the universe.”
“They ask us to work for it, to give something in return – to show up eating cleaner and having sacrificed some of our creature comforts, because we’re preparing for something divine and holy.”
Alongside giving up certain foods and substances, it’s advised to do a kind of “mental” diet as well. This means avoiding spending a lot of time consuming social media and dark media, and where possible, staying away from environments which may be stressful for you.
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Medical Contraindications
It’s also crucial to consider medical contraindications before drinking ayahuasca. If you have a history of serious mental illness including psychosis, bipolar, or schizophrenia, consult your doctor and the retreat center about whether or not it will be possible for you to participate. People with high blood pressure or heart problems should also consult with their doctor.
If you are taking any kind of prescription or over-the-counter medication, you should check with your doctor and the retreat center about whether or not this is safe. SSRI and other serotonergic medications, such as Prozac or Paxil, interact dangerously with ayahuasca. Ayahuasca acts as an MAO inhibitor, and combining the two can cause serotonin syndrome. These medications generally must be tapered well in advance under medical supervision, never abruptly on your own. Any good retreat center or ceremony facilitator should have an intake form that rules out those for whom ayahuasca is not safe to drink.
How To Prepare For Ayahuasca: Psychological Aspects
An ayahuasca retreat is not something you casually want to sign up for. It is typically something people want to do for a specific, important, and personal reason.
Set An Intention
You may find it beneficial to prepare psychologically for ayahuasca by setting your intentions for the experience.
Why do you want to take ayahuasca? What do you hope to gain from it? Your intentions might include the following.
- Using ayahuasca tea to help improve mental health issues
- To process past traumas
- Overcoming addiction
- To gain clarity on a certain situation or decision
- Healing a physical illness
- Connecting to your spirituality
- Dealing with a personal or existential crisis
- Learning more about yourself
- Learning more about the medicine and connecting to the spirit of the plants
- Or even for philosophical reasons, like trying to better understand the nature of consciousness and reality
Set your intentions by journaling, or perhaps speaking to someone about them beforehand. This could be a good friend, a partner, or a psychotherapist.
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How To Handle A Challenging Experience
Ideally, you will have trained, experienced facilitators with you during your ayahuasca experience. Not only will they look after your physical safety, they can also help you navigate any challenging aspects of the experience, such as states of anxiety, fear, panic, or confusion.
However, you can also prepare for ayahuasca by learning techniques for handling difficult experiences.
Some of these might include the following.
- Mindfulness. Noticing what is occurring during an experience without being either attached or aversive toward it.
- Focusing on your breath. This involves consciously taking deep breaths. A form of mindfulness that can bring your attention to the present moment, alleviating some distress you might be experiencing.
- Acceptance. Embracing what you are experiencing, rather than wanting challenging emotions or visions to disappear. Also known as “letting go”, this acceptance and lack of resistance can be useful when experiencing intense states like ego death.
- Self-Compassion. Showing kindness toward yourself during a difficult experience.
- Resolve: Telling yourself that you are capable of handling anything that the medicine throws at you.
- Reminding yourself that you are safe and not in danger. This is especially helpful when you experience fear, anxiety, or panic.
- Telling yourself that what you’re experiencing is because of ayahuasca. You haven’t lost your mind, and that you will be sober again in a matter of hours.
The Power of Meditation
Courtney, who has been working with ayahuasca and other plant medicines for 20 years, says that “when people ask me what is the single most powerful thing I could do to prepare to drink ayahuasca? It’s meditation.”
“And I don’t just mean the typical sit, meditate, and stillness. But walking in nature and letting that be a meditation. Music as a form of meditation. Dance as a form of meditation. The idea being anything that gets you out of your head, connected to heart consciousness, connected to your body.”
It isn’t necessary to become a master of meditation to prepare yourself for challenging moments of an ayahuasca experience. Nevertheless, being aware of the above techniques, practicing them a bit beforehand, and recalling them during an ayahuasca journey can prove to be incredibly helpful.
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Make Time For Integration
Psychological preparation can also mean making sure you have time for integration after your ayahuasca experience(s). Psychedelic integration describes the process of turning the lessons you receive from a psychedelic experience into concrete changes in your life. This could involve making changes to your attitudes, beliefs, habits, relationships, career, hobbies, plans, and goals.
Generally, the point of integration is to achieve a positive transformation, be that in how you see and treat yourself, how you manage the challenges life throws at you, how you view the world, or how you behave in your relationships.
Be sure to prepare for more than just the experience itself, but also for the period after it. This may entail many questions, heightened emotional states, confusion, and uncertainty.
For the purposes of integration, many ayahuasca users find it helpful to seek out a coach or therapist who is knowledgeable about psychedelics or altered states, or a psychedelic integration circle. Having access to either a 1:1 or group container can be crucial in holding you accountable to achieve your goals and providing a safe space to explore your experience.
In any case, being able to discuss the experience with anyone who is open-minded, non-judgmental, and supportive can help you during your process of integration.
How To Prepare For Ayahuasca: Practical Aspects
Finally, think practically about an ayahuasca retreat to ensure that the experience goes as smoothly as possible. This means doing the following.
- Understanding the legality of the retreat. Where is ayahuasca legal or decriminalized? If it’s not legal where you’re planning to drink it, are you comfortable with that?
- Doing your due diligence with regard to the training and reputation of the facilitators. It is psychologically and spiritually dangerous to take ayahuasca with someone who has not completed the many years of training required to serve ayahuasca, so make sure to establish that this is the case with your chosen facilitator before your commit.
- Making sure you have time to settle in the country the retreat is in. For example, if you’re traveling to Latin America for an ayahuasca retreat, you might want to spend some time resting and exploring before the ayahuasca sessions begin. This way, you won’t start ceremonies with pre-existing jet lag or travel-related stress.
- Ensuring you have a clear itinerary of how to get to the ayahuasca retreat.
- Taking everything with you that you might need.
- Having enough money available for any additional travel costs.
Discipline Equals Freedom
Ultimately, as Courtney argued, you get out what you put in with ayahuasca preparation. Many people will tell you that the medicine rewards discipline and sacrifice ahead of the ceremony, so it’s worth giving up some of your creature comforts in the name of deep healing and connecting with this ancestral tradition. If you’re eager to try ayahuasca but haven’t yet found a trustworthy retreat center, check out our guide on finding the right retreat for you.
Preparing Safely for Ayahuasca in 2026
The most important safety point comes first. Ayahuasca contains an MAO inhibitor, and that is what makes the DMT orally active. The same property also creates serious drug-interaction risk. Combining ayahuasca with SSRIs, SNRIs, or other serotonergic medications can cause serotonin syndrome, a potentially life-threatening reaction. Certain foods and many other medications also interact dangerously with MAO inhibitors.
Contraindicated medications should be tapered well in advance, often over several weeks, under medical supervision. Never stop antidepressants abruptly on your own, since that carries its own risks. Reputable retreats screen for a personal or family history of psychosis or bipolar disorder. They also screen for certain cardiac conditions. Thorough screening is one of the clearest markers of a safe retreat.
The traditional dieta asks you to avoid alcohol, recreational drugs, certain foods, and sexual activity for a period before ceremony. It serves both practical and ceremonial purposes. Vet any retreat for experienced facilitators, real medical screening, and emergency preparedness. Ayahuasca is unregulated in most settings, so your safety depends heavily on the container around you.
Frequently Asked Questions
- Can I take ayahuasca if I am on antidepressants?
- Not safely without stopping them first. Ayahuasca acts as an MAO inhibitor, and combining it with SSRIs, SNRIs, or other serotonergic medications can cause serotonin syndrome, a potentially life-threatening condition. Contraindicated medications must be tapered well in advance under medical supervision, never abruptly on your own.
- How long before ayahuasca should I stop my medications?
- It depends on the medication, but SSRIs and other contraindicated drugs are often tapered over several weeks before a ceremony. This must be done gradually and under medical supervision, both to avoid the ayahuasca interaction and to prevent withdrawal effects. Never stop antidepressants abruptly on your own.
- What is the ayahuasca dieta?
- The dieta is a period of dietary and lifestyle preparation before ceremony. It traditionally avoids alcohol, recreational drugs, certain foods (including aged, fermented, and high-tyramine foods that interact with MAOIs), and sexual activity. It serves both practical safety and ceremonial purposes.
- How do I choose a safe ayahuasca retreat?
- Look for retreats that conduct real medical and psychiatric screening, use experienced facilitators, and have emergency procedures in place. Screening should exclude contraindicated medications and a history of psychosis or bipolar disorder. A retreat that skips screening or rushes you is the biggest red flag.
