These Are The Most Common Psychedelic Side Effects and How To Deal With Them

These Are The Most Common Psychedelic Side Effects and How To Deal With Them

Medical psychedelics are compounds that are effective in the treatment of a medical condition, which are generally physical or psychological. The medical psychedelics that many researchers focus on include psilocybin (the active ingredient in magic mushrooms), ayahuasca, iboga, MDMA, and ketamine. These compounds — when coupled with psychotherapy — can help those struggling with severe, hard-to-treat, or treatment-resistant mental health conditions. But while effective, medical psychedelics can also entail some side effects.

You may find some of the side effects of medical psychedelics are unimportant and manageable. Others, meanwhile, can be a nuisance and make you feel quite uncomfortable during your experience. In this article, we are going to explore how to deal with the most common side effects of medical psychedelics. These side effects can be reduced or managed, and in some cases, they can even be prevented.

An Overview of Side Effects of Medical Psychedelics and Most Common Causes

Side EffectDescriptionCommon Psychedelics Causing Effect
Nausea and VomitingCommon with some psychedelics, varies by individualPsilocybin, Ayahuasca
DizzinessCan occur during usageLSD, Psilocybin
Lack of CoordinationTemporary effect during the experienceKetamine, LSD
Jaw Clenching / Teeth GrindingBruxism, or jaw clenching and teeth grinding, can lead to dental and oral damage if not managed properly.MDMA
Persistent Mental Health EffectsCan include changes in mood and perceptionLSD, MDMA, Psilocybin
HPPD (Hallucinogen Persisting Perception Disorder)Rare, involves lingering visual disturbancesLSD, Psilocybin

Nausea And Vomiting

Two of the more common side effects of psychedelics are nausea and vomiting, including psilocybin-containing mushrooms, ayahuasca, and iboga. Typically increasing with higher dosages, nausea can be mild, moderate, or severe. It’s also more common than vomiting when using psilocybin mushrooms. However, both nausea and vomiting are common following the ingestion of ayahuasca and iboga. See below for how to reduce both side effects from occurring:

  • Taking the psychedelic on an empty stomach and fasting beforehand can be helpful. This practice is commonplace with many ceremonies and retreats involving mushrooms, ayahuasca, and iboga.
  • Rectal administration: by taking the compound through the rectum (also called ‘plugging’), you bypass the stomach. This reduces nausea in the process. It’s important to note that this route of administration (ROA) can be unappealing to many. Also, for this ROA to be practical, you would want to take extracted or synthetic compounds, not the whole plant that contains those compounds. This would mean, for example, taking synthetic psilocybin or extracted ibogaine (found in the shrub Tabernanthe iboga).
  • Many studies have shown ginger to be effective at preventing nausea and vomiting. To prevent nausea and vomiting from medical psychedelics, eat raw ginger root, drink ginger tea (using fresh or powdered ginger), take a ginger supplement, or consume ginger-containing products. You can consume ginger before and during the dosing of psychedelics to deal with nausea.
  • Antiemetic drugs (those that are helpful for preventing and/or relieving nausea and vomiting) include dopamine antagonists (e.g. metoclopramide, haloperidol, domperidone, and levomepromazine), antihistamines (e.g. cyclizine, promethazine), serotonin 5HT3 antagonists (e.g. ondansetron, tropisetron, granisetron), and cannabinoids (e.g. cannabis, a cannabis extract, or CBD).


Dizziness is a side effect of medical psychedelics that can occur with psilocybin mushrooms, ayahuasca, iboga, and ketamine. You can deal with this dizziness by:

  • Lying down and closing your eyes until the dizziness passes, then getting up slowly.
  • Moving slowly and carefully.
  • Drinking water and staying hydrated (as dehydration can be a common cause of dizziness).

Also Read: Just what, exactly, is psychedelic therapy?

Lack Of Coordination

Medical psychedelics that can result in ataxia (a lack of coordination) include psilocybin mushrooms, ayahuasca, iboga, MDMA, and ketamine. This can involve finding it difficult to walk, speak, and perform everyday activities. When participating in a ceremony or treatment involving these medical psychedelics, you can deal with impaired coordination by:

  • Lying or sitting still.
  • Not having any obligations to walk around or perform any duties.
  • Having a guide, facilitator, or therapist present, who can ensure that you are physically safe.

Jaw Clenching And Teeth Grinding

Bruxism (jaw clenching and teeth grinding, also known as ‘gurning’) occurs most commonly with MDMA. For some people, bruxism is an inconvenient aspect of the MDMA experience, but in some cases, if it’s not managed, it can lead to issues such as tooth damage and damage to the lips, tongue, or cheeks, as a result of unconsciously chewing on them. However, significant damage from bruxism usually follows MDMA abuse. It is less likely to occur with something like clinical ketamine therapy, in which doses will be lower than used recreationally, and with only a few sessions taking place. But if you are worried about bruxism, you can deal with this side effect of MDMA by:

  • Using chewing gum or chewing on a pacifier, so you don’t grind your teeth together.
  • Taking a magnesium supplement: magnesium helps to increase levels in the brain and it is believed that the bruxism resulting from MDMA is related to how the drug decreases dopamine levels.

Persistent Mental Health Effects

In some instances, a negative psychedelic experience can lead to a persistent, negative impact on one’s mental health. This is more likely with traditional psychedelics like psilocybin mushrooms, ayahuasca, and iboga, rather than MDMA or ketamine. Negative, lasting effects can include anxiety, confusion, depersonalization (feeling like an outside observer of your life), and derealization (feeling detached from your surroundings). If these unpleasant effects don’t subside on their own and in a matter of weeks, you can:

  • Seek counseling or psychotherapy
  • Try to integrate your experience: by making sense of a psychedelic experience, you can lessen negative effects such as anxiety and confusion. Integration can take place within counseling or psychotherapy, on your own in the form of introspection, reading, and journaling, or among other psychedelic users in the form of a psychedelic integration group.
  • Practice self-care and look after your mental health: this can involve watching your diet, getting good quality sleep, exercising regularly, and having a regular meditation practice.
  • Use medications to manage the severity of the symptoms (best to speak with your primary doctor or mental health professional to discuss if medication is necessary and what sort of medication you might need).

Also Read: Here’s what to know about psychedelic side effects


Hallucinogen persisting perception disorder (HPPD) is a rare condition among psychedelic users. It involves the experience of visual distortions, even when the substance has been eliminated from the body. A lot of the time, HPPD will pass on its own, in a matter of weeks. But if it doesn’t, you should:

  • Refrain from using psychoactive substances, especially psychedelics.
  • Reduce your stress levels.
  • Seek treatment for any mental health issues occurring alongside the HPPD, such as depression and anxiety.
  • Use prescribed medications if nothing else works. Commonly prescribed medication for HPPD include benzodiazepines, such as alprazolam (Xanax) and clonazepam (Klonopin).

Clinic Spotlights:
Polaris Insight Center – San Francisco, California
Temenos Center for Integrative Psychotherapy – Petaluma, California
The Center for Transformational Psychotherapy – San Anselmo, California
IV Wellness Center – San Rafael, California
Mossbrae Medical Group – Mount Shasta, California
Colorado Springs Ketamine Treatment Center
Crestline Health and Wellness – Birmingham, Alabama
NeuroRelief Ketamine & Infusion Therapy – Sherman Oaks, California
Ketamine Infusion Centers – Phoenix, Arizona

Sam Woolfe

Sam Woolfe

View all posts by Sam Woolfe

Sam Woolfe is a freelance writer based in London. His main areas of interest include mental health, mystical experiences, the history of psychedelics, and the philosophy of psychedelics. He first became fascinated by psychedelics after reading Aldous Huxley's description of the mescaline experience in The Doors of Perception. Since then, he has researched and written about psychedelics for various publications, covering the legality of psychedelics, drug policy reform, and psychedelic science.

Dr. Ben Medrano

This post was medically approved by Dr. Ben Medrano

Dr. Ben Medrano is a board certified psychiatrist specializing in Integrative Psychiatry, Ketamine Assisted Therapy and Psychedelic Harm Reduction and Integration. He received his MD from the University of Colorado School of Medicine with additional training in the Urban Underserved Track (CU-UNITE). Dr. Medrano is most known for his work with ketamine assisted therapy and is the former Senior Vice President and US Medical Director of Field Trip Health - the largest in-office ketamine assisted therapy practice to date. He continues to sponsor Field Trip clinics as a local medical director at multiple sites on the East Coast allowing him to further the field of psychedelic assisted therapy and research.

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