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✓ Last verified: April 2, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Plus by APN offers interventional psychiatry and neurotechnology in a luxe and comfortable outpatient setting in Boulder, Colorado. Plus exists to help clients move through depression, OCD, anxiety, PTSD, and other mental health conditions.
Known For: Plus by APN (All Points North) in Boulder offers a modern, multi-modal approach to mental health treatment. The clinic provides IV and IM ketamine therapy alongside deep TMS, stellate ganglion block (SGB), intensive outpatient programs, and integrative psychiatry. In-network with major insurers including Anthem, Aetna, TRICARE, and UHC/Optum, Plus by APN makes advanced treatments more financially accessible.
| Google Reviews | ⭐ 4.7 (20+ reviews) |
| Location | Boulder, Colorado |
| Address | 1360 Walnut Street, Suite 110, Boulder, CO |
| Phone | (855) 510-4585 |
| Website | plusapn.com |
| Treatments | IV Ketamine, IM Ketamine, Deep TMS, Stellate Ganglion Block (SGB), IOP, Medication Management |
| Conditions Treated | Depression, Anxiety, PTSD, Trauma, OCD, Suicidal Ideation, Chronic Stress |
| Cost | Ketamine starting at $340/session |
| Insurance | In-network: Anthem BCBS, Aetna, TRICARE, UHC/Optum |
| KAP Available | Contact clinic for details |
| Clinical Lead | All Points North Clinical Team |
HealingMaps Take: Plus by APN Boulder brings institutional-grade mental health resources to the Boulder community. The breadth of treatment options—ketamine, deep TMS, SGB, IOP, and psychiatric medication management—means clinicians can layer therapies based on each patient’s response. The in-network insurance coverage with major carriers is a significant advantage, making ketamine therapy more accessible than at most private-pay-only clinics. Starting at $340 per ketamine session with potential insurance offset, this is one of the more cost-transparent options in the Colorado market.
Market Position: Plus by APN is an IV-ketamine-focused clinic in the Boulder metro — the most common cash-pay protocol in the HealingMaps verified directory.
Is Plus by APN Right for You?
✓ Choose Plus by APN if:
- You want supervised IV ketamine with real-time medical monitoring
- You prefer the shorter, lower-cost IM ketamine protocol
- You’re treating co-occurring depression and PTSD
✗ Look elsewhere if:
- You need Spravato (FDA-approved esketamine) covered by your insurance
- You want ketamine-assisted psychotherapy (KAP) with integrated talk therapy
- You’re seeking ketamine for chronic pain (this clinic focuses on mental health)
Plus by APN Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
Estimated per session
$525–$900
Range: $450–$1,500/session
Estimated total program
$3,150–$5,400
Range: $2,700–$9,000/6-session series
Select a treatment type to see pricing context.
Ketamine Protocols Compared — What’s Offered at Plus by APN
Industry pricing reference. Plus by APN’s posted price: Ketamine starting at $340/session. Contact the clinic for any package or sliding-scale options. The calculator above shows metro-level cost estimates across protocols.
| Protocol | Typical Industry Cost | Offered Here |
|---|---|---|
| IV Ketamine | $350–$650/session | ✓ Yes |
| Spravato (esketamine) | $0–$250 copay (insured) | — |
| IM Ketamine | $250–$400/injection | ✓ Yes |
| KAP (with therapist) | $400–$1,200/session | — |
| At-home troches | $150–$300/month | — |
What to Expect at Your First Plus by APN Appointment
- Initial intake call — Brief medical history review, depression and anxiety screening, and medical clearance for IV ketamine. Call (855) 510-4585 to schedule. Plus by APN’s posted pricing: Ketamine starting at $340/session.
- Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Plus by APN clinical team.
- First treatment session — supervised IV ketamine infusion in a private treatment room, lasting approximately 60–90 minutes (40-minute infusion + recovery). Sessions are held at 1360 Walnut Street, Suite 110, Boulder, CO. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
- Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your IV session.
What to Ask on Your Plus by APN Consult Call
- How long has the Plus by APN clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
- Does Plus by APN provide a superbill for out-of-network insurance reimbursement, and what’s a typical 6-session total cost including any follow-up?
- Colorado’s Natural Medicine Health Act covers certain psychedelics — how does your ketamine practice integrate with broader psychedelic-therapy options patients may consider?
- What does Plus by APN recommend for patients who don’t respond to the standard 6-session acute series?
Boulder Ketamine Market Snapshot
Sources: CDC PLACES 2023 (Boulder County, CO, crude prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.
- Adult depression in Boulder County, CO: 23.5%
- Frequent mental distress (14+ days per month): 15.2%
- Adults lacking health insurance: 7.8%
- Boulder County population: 328,658 · median household income $99,770
- Recent Boulder-area inquiries to HealingMaps: A growing stream of Colorado residents have recently contacted us seeking ketamine care
Behind this data: HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,473 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.
From the 2026 Ketamine Industry Report
Treatment-resistant depression — typically defined as failure on two or more antidepressant trials — is the FDA-approved indication for Spravato and the most common clinical qualifier for ketamine therapy insurance coverage. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.
Patient Questions about Plus by APN
This 4-question summary is matched to the protocols and conditions Plus by APN treats. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
What ketamine protocols does Plus by APN offer?
Plus by APN offers IV ketamine and IM ketamine — a 2-protocol practice. Patients can switch between or combine modalities without changing providers. Confirm specific dosing schedules and which protocols are recommended for your condition during your consult.
Is Plus by APN suited for treatment-resistant depression?
Plus by APN treats depression via IV ketamine (off-label, evidence-based). Insurance coverage is rare for IV/KAP — most patients pay out of pocket. TRD is typically defined as two or more prior antidepressant trials without sufficient response — patients meeting that bar are best candidates here.
Does Plus by APN treat PTSD?
Yes — Plus by APN treats PTSD. Ketamine for trauma differs from depression treatment: dosing is often lower per session, and pairing the protocol with trauma-focused therapy between sessions is common. A reasonable consult question: whether PTSD patients here typically use ketamine alone or alongside an outside therapist.
Can Plus by APN help with anxiety disorders?
Yes — Plus by APN treats anxiety, including generalized anxiety, social anxiety, and panic disorder. The evidence base for ketamine in anxiety is less robust than for depression, but it can be a meaningful option for patients who haven’t responded to SSRIs or benzodiazepines. Worth asking which of their protocols they typically recommend for anxiety-primary patients.
TMS therapy is also available at this clinic. Unlike cash-pay ketamine, TMS is covered by most major insurance plans for treatment-resistant depression. TMS is FDA-cleared for treatment-resistant depression (since 2008), OCD via Deep TMS, anxious depression, and adolescent MDD ages 15–21. This clinic uses BrainsWay Deep TMS, the only TMS device with standalone FDA clearance for OCD via the H7 coil. Read our complete guide to TMS therapy for FDA-cleared conditions, device differences, insurance coverage by carrier, and what to expect at your first appointment. Browse verified TMS clinics in our directory.
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