✓ Last verified: February 14, 2026 — Edited & verified by Angelica Bottaro for HealingMaps Editorial Staff
Plus by APN offers interventional psychiatry and neurotechnology in a comfortable outpatient setting near Denver, Colorado. Plus exists to help clients move through depression, OCD, anxiety, PTSD, and other mental health conditions.
Services include Deep Transcranial Magnetic Stimulation (dTMS), neurofeedback, ketamine-assisted healing and therapy, stellate ganglion block (SGB), qEEG, psychiatric evaluation, med management, and therapy. Plus is staffed by compassionate, experienced health professionals who go above and beyond to make sure your care is custom-curated to your exact needs and goals.
Market Position: Plus by APN treats both depression and PTSD — the two most common ketamine therapy indications, accounting for 34% of HealingMaps patient inquiries.
Is Plus by APN Right for You?
✓ Choose Plus by APN if:
You’re seeking verified ketamine therapy in the Denver metro
✗ Look elsewhere if:
You want ketamine-assisted psychotherapy (KAP) with integrated talk therapy
You’re seeking ketamine for chronic pain (this clinic focuses on mental health)
Plus by APN Ketamine Cost Calculator
How Much Will Ketamine Therapy Cost?
Estimate your out-of-pocket range based on patient-reported pricing and HealingMaps proprietary clinic data.
Estimated per session
$525–$900
Range: $450–$1,500/session
Estimated total program
$3,150–$5,400
Range: $2,700–$9,000/6-session series
Your estimate vs. national patient-reported medianBased on national tracking, adjusted for Manhattan, NY market
Select a treatment type to see pricing context.
Get matched to verified clinics
A HealingMaps specialist will follow up within one business day with providers that match your estimate, protocol, and insurance situation.
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A HealingMaps specialist will reach out within one business day with clinic matches based on your estimate. In the meantime, review the verified providers below.
⚠ FDA-cleared indications for TMS therapy: treatment-resistant major depressive disorder (MDD), obsessive-compulsive disorder (OCD, Deep TMS only), anxious depression, short-term smoking cessation, and adolescent MDD (ages 15–21). Use of TMS for other conditions including PTSD, bipolar depression, fibromyalgia, and other indications is off-label — not currently FDA-cleared for those specific indications. Discuss your condition with the clinic to understand insurance coverage and clinical evidence.
What to Expect at Your First Plus by APN Appointment
Initial intake call — Medical history review and clinical eligibility check.
Medical evaluation — in-person or telehealth psychiatric assessment, vitals check, and review of current medications with the Plus by APN clinical team.
First treatment session — supervised ketamine therapy session in a private treatment room, lasting approximately 60–90 minutes. You’ll have a comfortable chair or recliner, dim lighting, and direct medical monitoring throughout.
Recovery and follow-up — observation period after dosing, mood check-in with the clinical team, and scheduling your next session. Arrange for a ride home; do not drive for 24 hours after your ketamine session.
What to Ask on Your Plus by APN Consult Call
How long has the Plus by APN clinical team been delivering ketamine therapy, and what specialty training do your providers hold?
What’s a typical 6-session total cost at Plus by APN, and do you offer payment plans, HSA/FSA-eligible billing, or sliding-scale pricing?
Colorado’s Natural Medicine Health Act covers certain psychedelics — how does your ketamine practice integrate with broader psychedelic-therapy options patients may consider?
What does Plus by APN recommend for patients who don’t respond to the standard 6-session acute series?
Patient Questions about Plus by APN
This 4-question summary covers the most common patient questions for ketamine clinics in Denver, Colorado. Editorial responses are HealingMaps-authored, grounded in our 2026 Ketamine Clinic Intelligence Report.
What ketamine treatments does Plus by APN offer?
Plus by APN offers verified ketamine therapy services in Denver. Specific protocols can include IV ketamine infusion, IM ketamine injection, oral troches, ketamine-assisted psychotherapy (KAP), or Spravato (FDA-approved esketamine) — verify the specific protocol mix with the clinic during your consult call. Multi-protocol practices typically offer more flexibility for matching the modality to your diagnosis and insurance coverage.
Is Plus by APN suited for treatment-resistant depression?
Treatment-resistant depression (TRD) — typically defined as failure on two or more antidepressant trials — is the most common qualifier for ketamine therapy and the FDA-approved indication for Spravato. Patients meeting that bar are typical candidates at ketamine clinics like Plus by APN. If insurance coverage matters, ask whether they offer Spravato (insurance-covered for TRD) versus IV ketamine (typically self-pay).
Does Plus by APN treat PTSD, anxiety, or chronic pain?
Most ketamine clinics treat PTSD and anxiety alongside depression — these three conditions account for ~46% of HealingMaps patient inquiries. Some clinics also treat chronic pain (CRPS, fibromyalgia, neuropathic pain), though pain protocols differ from mental-health protocols (longer infusion times, higher doses). Ask Plus by APN which specific conditions they treat most often and how their protocols differ by indication.
How does Plus by APN compare to other ketamine clinics in Denver, Colorado?
Compare ketamine clinics in Denver, Colorado on three axes: (1) protocol mix — multi-protocol clinics offer flexibility; (2) clinical lead — psychiatrist-led clinics typically include KAP integration, anesthesiologist-led clinics typically focus on infusion; (3) insurance posture — Spravato-certified providers can run insurance coverage; cash-only IV clinics cannot. Plus by APN’s positioning on these axes determines whether it’s the right fit for your specific diagnosis and budget.
Denver Ketamine Market Snapshot
Sources: CDC PLACES 2023 (Denver County, CO, crude prevalence) · U.S. Census ACS 5 Year · HealingMaps proprietary patient inquiry data.
Adult depression in Denver County, CO: 22.7%
Frequent mental distress (14+ days per month): 15.2%
Adults lacking health insurance: 12.1%
Denver County population: 710,800 · median household income $85,853
Recent Denver-area inquiries to HealingMaps: A growing stream of Colorado residents have recently contacted us seeking ketamine care
Behind this data:HealingMaps has analyzed 23,496 patient inquiries (Oct 2022 – Mar 2026), mapped 1,473 verified clinics across 3,142 counties, scraped 132 clinic pricing pages, and collected 658 practitioner survey responses. This snapshot reflects our multi-source methodology.
From the 2026 Ketamine Industry Report
11.4% of ketamine inquiries cite anxiety as the primary condition — the third-most-common driver of demand after depression and PTSD. Source: HealingMaps 2026 Ketamine Clinic Intelligence Report — drawn from 23,496 patient inquiries and 132 clinic website analyses.
This clinic also offers TMS therapy as an FDA-cleared, insurance-covered option for patients with treatment-resistant depression. Patients drive themselves to and from sessions, return to work the same day, and need no chaperone or recovery period. This clinic uses BrainsWay Deep TMS, the only TMS device with standalone FDA clearance for OCD via the H7 coil. Read our complete guide to TMS therapy for FDA-cleared conditions, device differences, insurance coverage by carrier, and what to expect at your first appointment. Browse verified TMS clinics in our directory.
The Healing Maps Editorial Team has decades of experience across all facets of the psychedelic industry. From assessing studies and clinic research, to working with clinician's and clinics, we help provide data-backed information to psychedelic-curious individuals across the globe.
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