Find semaglutide, tirzepatide, and GLP-1 weight-loss clinics in your area.
Semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) are the two most-prescribed GLP-1 weight-loss medications in the United States. Both are FDA-approved, once-weekly injections that work by mimicking the incretin hormones your body produces after eating — slowing gastric emptying, reducing appetite, and improving insulin response. Clinical trials have shown average weight loss of 15–22% of body weight over 68–72 weeks at the highest approved doses.
In early 2026 Novo Nordisk cut GLP-1 prices up to 70%, bringing semaglutide’s cash-pay cost to roughly $150 per month. Compounded versions through licensed 503A and 503B pharmacies remain widely available at $200–$500 per month, depending on the compound and clinician model.
Nearby GLP-1 & Semaglutide Clinics
Displaying GLP-1 weight-loss clinics near: Columbus, Ohio US
How to Choose a GLP-1 Clinic
Most GLP-1 programs now follow a similar structure: a short medical intake (often virtual), a prescription filled by either a brand-name or 503A compounding pharmacy, weekly self-injection at home, and monthly or quarterly follow-up visits. The differences between clinics come down to four things:
- Licensed clinician oversight — MD, DO, NP, PA-C, or ND prescribing with baseline labs before starting.
- Pharmacy source — branded (Wegovy, Zepbound, Ozempic, Mounjaro) vs. compounded through 503A/503B pharmacies. Both are legitimate; compounded is typically 50–70% cheaper.
- Titration schedule — how gradually the dose is increased. Slower titration reduces GI side effects.
- Ongoing monitoring — weight, lab work, side-effect check-ins. Avoid clinics that hand out a script with no follow-up.
Semaglutide vs. Tirzepatide vs. Retatrutide
The three most-searched GLP-1 compounds today are semaglutide, tirzepatide, and (for those following the category) retatrutide. The short version: tirzepatide produces more weight loss on average (~22%) than semaglutide (~15%) in head-to-head trials. Retatrutide, a triple-agonist in Phase 3 trials, has shown even higher weight loss but is not yet FDA-approved. For a full comparison, read our Semaglutide vs. Tirzepatide guide and our Tirzepatide vs. Retatrutide guide.
GLP-1 FAQs
Is semaglutide legal to prescribe?
Yes. Semaglutide is FDA-approved under three brand names: Wegovy (weight loss), Ozempic (type 2 diabetes), and Rybelsus (oral, diabetes). Compounded semaglutide is also legal through licensed 503A and 503B pharmacies with a clinician prescription.
What does GLP-1 therapy cost in 2026?
Novo Nordisk cut branded GLP-1 prices in early 2026, bringing cash-pay costs to roughly $150/month for semaglutide and $200/month for tirzepatide. Insurance coverage varies — some plans cover GLP-1s for obesity, many do not. Compounded versions through 503A pharmacies typically run $200–$500/month.
How much weight will I lose on semaglutide or tirzepatide?
On the highest approved doses, clinical trials showed average weight loss of about 15% of body weight on semaglutide (STEP 1, 68 weeks) and about 22% on tirzepatide (SURMOUNT-1, 72 weeks). Individual response varies significantly. Tirzepatide has produced more weight loss than semaglutide in head-to-head trials.
What happens when I stop taking it?
Weight regain is common. Trial extension data showed patients who stopped semaglutide regained about two-thirds of the weight they had lost within a year. Both medications are generally considered long-term therapies rather than short-term interventions. Lifestyle changes improve maintenance but don’t fully prevent regain in most patients.
Can I take GLP-1s alongside other peptides?
Yes, many clinics stack GLP-1s with other peptides. Common pairings: BPC-157 for joint pain that can emerge during rapid weight loss, and CJC-1295/Ipamorelin for preserving lean mass. Any stack should be clinician-directed.