The Sacred Power of Plants: What, Exactly, Are Entheogens?
Last reviewed and updated: June 20, 2026.
Key Takeaways
| Definition | “Generating the divine within” (Greek) — psychoactive substance used in sacred/ceremonial context; term coined 1979 by Schultes, Ruck et al. |
| vs. “Psychedelic” | Same pharmacology; different framing — entheogen implies sacred intent, preparation, and cultural tradition; psychedelic is neutral/clinical |
| Classical entheogens | Psilocybin mushrooms, peyote, ayahuasca, ibogaine, cannabis (in specific traditions) |
| Legal protections | Peyote (Native American Church); ayahuasca (UDV/Santo Daime); psilocybin (Oregon/Colorado); most others Schedule I with narrow religious exemptions |
| Policy relevance | Oregon, Colorado ballot measures shaped by entheogenic framing; indigenous rights advocates use “entheogen” to invoke RFRA religious freedom protections |
An entheogen is a term that people use to describe psychedelics. In fact, some people will use this term as an alternative to “psychedelic”, preferring its use for different reasons. It may not be a common term that people use to refer to psychedelic substances but it is one that is worth exploring, especially since its meaning is quite distinct from “psychedelic”.
We estimate that 7.5% of the world’s population live in a country where at least one entheogen is legal.
Let’s take a look at the meaning of the term entheogen, describe the history of the term, compare and contrast it to alternative terms for these compounds. We then offer some analysis on why the term is appropriate for some people and inappropriate for others.
Here is a List of Entheogens, Their Effects, And Their Sources
| Entheogen | Effects | Common Experience | Natural Source |
| Psilocybin (Magic Mushrooms) | Hallucinations, time distortion, introspection, emotional intensity | Visual distortions, deep emotional and philosophical insights, feeling of oneness with the universe | Psilocybe and other mushroom species |
| DMT (Dimethyltryptamine) | Intense visual hallucinations, altered perception of time and reality, euphoria | “Breakthrough” experiences, encountering “entities”, out-of-body experiences | Various plant species; also produced endogenously in small amounts |
| Ayahuasca (DMT + MAOIs) | Hallucinations, intense emotional and psychological introspection | Visions often involving snakes or jaguars, purging, profound life insights | Banisteriopsis caapi vine combined with plants containing DMT |
| LSD (Lysergic acid diethylamide) | Altered thoughts and feelings, visual hallucinations, time distortion | Synesthesia, spiritual or transcendental experiences, altered perception of reality | Synthetic, derived from ergot fungus |
| Mescaline (Peyote, San Pedro) | Altered perception, hallucinations, introspection, euphoria | Visual distortions, emotional insight, increased empathy and sociality | Peyote cactus, San Pedro cactus, Peruvian Torch cactus |
| Ibogaine | Hallucinations, introspection, stimulant at lower doses | Visions, replay of life events, often used in addiction treatment | Iboga shrub |
| Salvia Divinorum (Diviner’s Sage) | Intense hallucinations, altered perception of reality, time distortion | Sensation of traveling through time/space, “becoming” inanimate objects, often described as more “bizarre” than pleasant | Salvia divinorum plant |
| Cannabis | Mild hallucinations at high doses, relaxation, altered perception | Introspection, euphoria, altered sense of time, increased appreciation for music and art | Cannabis plant |
| 5-MeO-DMT (Toad venom) | Intense hallucinations, altered perception of reality, potential for ego dissolution | Experiences of merging with the universe or “God”, can be overwhelming | Certain species of toads, and various plants |
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The Meaning Of The Term “Entheogen”
Entheogen (also known as entheogenics, or entheogenesis) comes from the Greek word entheos, which means “the god (divine) within” and gen, which means “creates” or “generates”. So the literal translation of entheogen is “generating the divine within”. An entheogen is any substance that has the ability to achieve this.
These psychoactive substances are usually found in plants or fungi but they sometimes exist in the secretions of non-human animals as well, such as toads.
The Sense Of The Divine
To be an entheogen, a substance should be capable of inducing a spiritual or mystical experience, in which the user feels a sense of the divine. This sense of the divine can be experienced in a range of ways.
- The feeling that there is a divine presence during an experience
- Feeling oneself becoming divine or merging with the divine
- Coming into contact a religious conception of the divine, such as specific deities
- Receiving messages, insights, inspiration, and healing from this divine presence or being
- Communicating with a divine consciousness
Mystical States
People may use the term entheogen more broadly, however, to refer to any substance that can lead to mystical states. As well as a sense of the divine, these experiences can involve the below.
- Ego dissolution
- A feeling of being unified with the universe
- The sense of gaining insights into important truths
- A feeling of existing outside time and space
- The feeling of experiencing ultimate reality
- Ecstasy and bliss
- Ineffability
The Traditional Use Of Entheogens
Entheogen also refers to the psychoactive plants and mushrooms that people use in traditional, sacred contexts. This includes the ritualistic use of these psychoactive substances for religious, magical, shamanic, or spiritual purposes. Such use exists all over the world, in many different cultures. Some examples (both historical and present) include the following.
- Using peyote, morning glory seeds, magic mushrooms, salvia, and the dried skins of toads of the Bufo genus in North America
- The use of San Pedro, yopo, and ayahuasca in South America
- Using Tabernanthe iboga in Central West Africa
- The use of the Amanita muscaria mushroom in Siberia
The History Of The Term
In 1979, a group of ethnobotanists and scholars of mythology (Carl Ruck, Jeremy Bigwood, Danny Staples, Richard Evans Schultes, and R. Gordon Wasson) coined the term entheogen. They proposed it as an alternative to pejorative terms such as “hallucinogen” and “psychedelic”. They believed it more accurately conveyed the “transcendent and beatific states of communion with deity”. Ruck and others state the following:
“In a strict sense, only those vision-producing drugs that can be shown to have figured in shamanic or religious rites would be designated entheogens, but in a looser sense, the term could also be applied to other drugs, both natural and artificial, that induce alterations of consciousness similar to those documented for ritual ingestion of traditional entheogens.”
The term entheogen is meant to reflect the perspectives of indigenous peoples who traditionally use these substances. This perspective includes the belief that these substances have spiritual properties and intelligence. Ruck (2004) defined an entheogen as “any substance that, when ingested, catalyzes or generates an altered state of consciousness deemed to have spiritual significance”.
Entheogen vs. Other Terms
Let’s now examine why Ruck and these other authors wanted to use the term entheogen as an alternative to “hallucinogen” and “psychedelic”.
Entheogen vs. Hallucinogen
Ruck et al. argued that the term hallucinogen was inappropriate, given its etymological relationship to words related to delirium and insanity. They thought this term was pejorative, implying false and deluded perceptions.
Indeed, hallucinations, which hallucinogens supposedly induce, refer to the perception of a non-existent object or event. Many people who use these psychoactive substances, however, believe they are perceiving something real.
Entheogen vs. Psychedelic
In 1956, the psychiatrist Humphry Osmond and writer Aldous Huxley exchanged a series of letters, discussing what term should be used to refer to substances like mescaline and LSD. (Huxley famously took mescaline under the supervision of Osmond in 1953, an experience recounted in his 1954 book The Doors of Perception.)
Huxley suggested the term phanerothyme (from the Greek phanein, “to reveal” and thymos, “mind, soul”). This term literally meant “soul-revealing”. Osmond proposed, instead, the term psychedelic (from the Greek psyche, “mind” and delos, “manifesting”). The literal translation of this term is “mind-manifesting”. Psychedelic, as we all know, is the term that stuck.
Many people prefer the term psychedelic to hallucinogen as it does not carry the same negative connotations. Also, “mind-manifesting” is much broader and can encapsulate more aspects of the psychedelic experience than hallucinogen, which focuses just on hallucinations. Psychedelics do not always induce hallucinations, so many find that the term hallucinogen is inappropriate.
However, Ruck et al. thought the term psychedelic was also problematic since it sounded similar to words related to psychosis. Also, the term had become irreversibly associated with 1960s drug subculture. Entheogen, on the other hand, avoids these connotations.
People may prefer to use the term entheogen to emphasize the spiritual effects of these substances. It may be chosen to contrast with recreational use of the same drugs.
Entheogen vs. Plant Medicine
Another popular term referring to entheogens is “plant medicine”. These include certain psychoactive plants and mushrooms. It also refers exclusively to natural psychoactive substances. An entheogen, meanwhile, may include synthetic or semi-synthetic compounds capable of inducing mystical states, such as LSD, 2CB, and DPT.
One reason to prefer the term plant medicine over entheogen is that the former underscores the healing power of these compounds. Many people prefer to view these psychoactive plants and mushrooms as medicines, capable of promoting psychological health. The term entheogen, on the other hand, focuses more on spiritual effects. Some users might relate strongly to the healing potential of these compounds but not to concepts like the “divine”.
The Term Entheogen Makes Sense For Some People, But Not Others
There is a sense in which the term entheogen is justified. Research shows that it is common for people to have “God encounter experiences” under the influence of classic psychedelics like psilocybin, LSD, ayahuasca, and DMT. Psychedelic-occasioned religious experiences are often interpreted as an encounter with God (i.e. the God of the user’s understanding), a higher power, ultimate reality, or an emissary of God (e.g. an angel). The attributes of this “divine” presence include the below.
- Benevolence
- Intelligence
- Sacredness
- Eternity
- Omniscience (knowing everything)
- Agency (the ability to affect outcomes in reality)
- Existing in another dimension
However, not all users have had God encounter experiences when using psychedelics. For this reason, they may not find the term entheogen is appropriate. They might find that the term psychedelic is preferable since it is broader and better describes what their experience was like. After all, these compounds can manifest your mind — various thoughts, insights, feelings, and emotions — without necessarily manifesting a divine being.
Moreover, some users of these psychedelics may have experiences involving the perception of an outside presence or entity but choose not to attach labels to it like “divine”, “God”, or “spirit”. If you subscribe to a secular, atheistic, or naturalist worldview, then these terms may not make sense for you.
Indeed, many users find that their perception of this outside presence or being is a reflection or aspect of themselves. The experience, then, is a manifestation of their mind, rather than the appearance of a totally separate being existing in another reality. In this case, the term psychedelic would more accurately convey the nature of this experience than entheogen.
In Conclusion
As we can see, the decision to use (or not use) the term entheogen depends on a particular person’s religious or metaphysical worldview.
For those who describe these compounds as entheogens, the experiences they provide are deeply meaningful and profound. They play a central and important role in many people’s spiritual life and allow them to connect with something greater than themselves. For this reason, people may find it especially problematic that these substances are illegal. This means that people are being prevented from fully engaging in spiritual life as they see fit, with the threat of legal punishment if they take these substances.
However, the legal landscape surrounding psychedelics is slowly changing. Across North America, laws relating to the possession of psychedelics are relaxing. Soon it may be possible for people to have spiritual experiences; and not just in a medical context. Many people want the freedom to have experiences with psychedelics in a sacred context, without having to travel to countries where it is legally permissible to do so.
Why “Entheogen” Has Gained Policy Relevance in 2025
Since this article was written, the word “entheogen” has moved from an academic and counterculture term into the language of legislation and formal policy — a shift that has real implications for how these substances are regulated and framed publicly.
Oregon used “entheogen” in policy contexts. Oregon’s Measure 109 (2020), which legalized supervised psilocybin services, was developed in a context where advocates deliberately framed psilocybin using both clinical and entheogenic language. The Oregon Psilocybin Services program that emerged uses clinical terminology, but the advocacy discourse that built the ballot measure drew heavily on entheogenic framing — emphasizing the spiritual, healing, and intentional use traditions behind psilocybin, not just its pharmaceutical applications. This framing was intentional: it spoke to a broad coalition that included spiritual seekers and indigenous tradition-holders alongside clinical researchers.
Colorado’s Proposition 122 used “natural medicine.” Colorado’s 2022 ballot measure (Prop 122, Natural Medicine Health Act) explicitly chose the term “natural medicine” over both “psychedelic” and “entheogen” — a deliberate framing choice intended to be maximally palatable to voters who might be put off by either term. The substances covered (psilocybin, psilocin, DMT, mescaline, and ibogaine) have all been used in entheogenic contexts for generations, but the legislative framing emphasized healing and medicine over spirituality. This illustrates how the choice of terminology shapes policy outcomes: different terms activate different associations and constituencies.
The entheogen framing and indigenous rights. One dimension the article touches on but that has become more prominent since its publication: the relationship between entheogenic plant traditions and indigenous sovereignty. As the U.S. market for psilocybin, ayahuasca, and mescaline develops, there is growing advocacy for legal frameworks that explicitly protect indigenous ceremonial use and give indigenous communities standing in the development of regulatory systems. The 1994 Religious Freedom Restoration Act already protects Native American Church use of peyote (mescaline), but advocates argue that this protection has not been extended adequately to other indigenous plant medicine traditions. The entheogen framing — which explicitly honors the sacred, intentional, and culturally-embedded nature of these substances — is central to these indigenous rights arguments.
Frequently Asked Questions
What is an entheogen, and how is it different from a psychedelic?
An entheogen (from the Greek: “generating the divine within”) is a psychoactive substance used in a sacred, spiritual, or ceremonial context — with the intent of generating a mystical or religious experience. The term was coined in 1979 by scholars including ethnobotanist Richard Evans Schultes and philosopher Carl Ruck as an alternative to “psychedelic” (which means “mind-manifesting”) that better captured the intentional, sacred use of substances like psilocybin, peyote, ayahuasca, and ibogaine in indigenous traditions. The pharmacological effects are identical — what differs is the framing, intent, and context of use. All entheogens are psychedelics in the pharmacological sense; not all psychedelics are entheogens (if used recreationally with no spiritual intent, the entheogen framing doesn’t apply).
What plants and substances are considered entheogens?
The most historically established entheogens include psilocybin mushrooms (used in Mesoamerican religious traditions for thousands of years), peyote (the primary sacrament of the Native American Church, with documented ceremonial use for centuries), ayahuasca (the central sacrament of numerous Amazonian indigenous traditions, as well as syncretic Brazilian religious groups like Santo Daime), ibogaine (used in the Bwiti tradition of Central Africa), and cannabis (used in various Hindu and Rastafarian traditions). LSD, MDMA, and synthetically produced compounds are sometimes called entheogens when used with spiritual intent, but this use is more contested — the classical entheogen concept is tied to plants and fungi with long traditions of sacred use.
Are entheogens legal in the United States?
The legal picture is mixed and evolving. Peyote is protected for ceremonial use by enrolled members of federally recognized tribes under the Religious Freedom Restoration Act and American Indian Religious Freedom Act. Ayahuasca is protected for use by two specific religious organizations (União do Vegetal and Santo Daime) under court rulings based on the Religious Freedom Restoration Act — but not for general public use. Psilocybin mushrooms are available through licensed service centers in Oregon and for personal possession in Colorado (Prop 122). DMT (a key component of ayahuasca) remains Schedule I except in protected religious contexts. Several cities have passed broad decriminalization ordinances. The legal landscape is rapidly shifting in ways favorable to entheogenic plant access.
Why do some people prefer “entheogen” over “psychedelic”?
Several reasons: (1) The entheogen framing honors the indigenous, sacred, and intentional contexts in which many of these substances have been used for generations — “psychedelic” emerged from Western counterculture and clinical research contexts and can feel culturally reductive. (2) “Entheogen” implies intentionality and set/setting — the idea that these substances are most appropriate in sacred, prepared, and supported contexts, not as recreational drugs. (3) For advocates working at the intersection of plant medicine and indigenous rights, “entheogen” is the politically appropriate term because it connects to legal protections (religious freedom) that recreational framing does not. (4) Some clinical researchers prefer it because it centers healing and meaning-making, which aligns with therapeutic goals, rather than purely pharmacological framing.
