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The Synthesis wellness center, based in Amsterdam, Netherlands, offers Synthesis Core psilocybin mushroom three-day retreats. The team at Synthesis Amsterdam take the cutting-edge research into psychedelic truffles and combine it with generations-old wisdom traditions to create a unique and enlightening growth and wellness experience.

Participants in the Synthesis Core retreat have reported increased sense of well-being, positive mood, reduced stress, and a greater sense of connectedness after their time at Synthesis.

The lead facilitator at Synthesis is James Clifton. James brings over 30 years of experience with many of the world’s “perennial philosophies”, and he brings this wealth of wisdom to the retreats he guides. James’ training with trauma and addiction assists him in helping participants navigate the psychedelic experience.

The experiences at Synthesis are designed to promote growth and open the mind to possibility.

Psilocybin Treatments Offered

  • Mushrooms

Important Information

  • Synthesis is not equipped to offer psychedelic therapy at this time.
  • Although based in Amsterdam, Synthesis retreat locations are outside of the city.
  • Synthesis Core is currently unable to provide retreats to individuals using anti-depressants.
  • The Synthesis Core retreat is held at either the Venwoude or Zeeveld locations
  • Due to COVID-19 concerns and protocols, Synthesis is currently unable to provide retreats.


Synthesis Core is the “flagship three-day retreat” offered by Synthesis. The Core retreat is an opportunity to prepare for big changes in life or to bolster creative and productive energies. Your retreat begins with a preliminary call to Synthesis to discuss any medical concerns.

Along with truffle experiences, each retreat also focuses on ways to improve mood, focus, and states of consciousness in one’s daily life.

  • $3,000 USD/participant
  • 3-day / 2-night Accommodations
  • 1-on-1 preliminary discussions with facilitators
  • One psilocybin mushroom ceremony
  • Final day integration workshop

Contact Information

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What You Need to Know About Magic Mushrooms

Magic mushrooms are psychedelic because they contain the psychedelic compounds psilocybin and psilocin. They are also a completely natural psychedelic. Psilocybin is a prodrug, meaning it is only psychoactive when consumed and processed in the body.

When taking mushrooms containing psilocybin, the body will convert the psilocybin into psilocin, which is psychoactive. Both psilocybin and psilocin belong to a group of chemicals known as tryptamines. This grouping also includes compounds like DMT and 5-MeO-DMT.

Magic mushroom use is thousands of years old, but the idea largely entered public awareness with the publication of an article about magic mushrooms in Life magazine in 1957. Written by the then vice-president of J.P. Morgan R. Gordon Wasson, this article detailed a magic mushroom ceremony in Oaxaca, Mexico that Wasson took part in. In the decade that followed, more Westerners began experimenting with psilocybin mushrooms.

Today, promising new research trials have found that psilocybin can effectively treat a number of intransigent psychiatric conditions. It’s why psychedelics for depression and other mental health issues are becoming more popular these days.

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