5 Best Ketamine Clinics in Portland (2026) — Verified & Reviewed

• By Healing Maps Editorial Staff
• October 5, 2022April 27, 2026
• Ketamine Articles ketamine therapy ketamine treatment
• With 1 comment

Portland is a national leader in psychedelic-informed mental health care, and its ketamine therapy scene reflects that progressive spirit. From anesthesiologist-led infusion clinics to psychedelic-integrated practices, the city offers a range of approaches for treatment-resistant depression, PTSD, chronic pain, and more.

5 Best Ketamine Clinics in Portland: How We Chose Which Clinics Make the List

Our editorial team evaluated each Portland clinic on provider credentials, patient reviews across Google and Yelp, treatment modalities, pricing transparency, and therapeutic approach. Every clinic listed has been verified as currently operating and accepting new patients.

The Best Ketamine Clinics in Portland

1. Portland Ketamine Clinic

Known For: One of only two Oregon clinics licensed for IV ketamine, with a board-certified anesthesiologist and spa-like treatment environment

Why We Picked Them: Portland Ketamine Clinic combines anesthesiology expertise with a patient-first approach that has earned near-perfect ratings across Google and Yelp. Dr. Abreu’s 20+ years of anesthesia experience provides an extra layer of safety and dosing precision.

The clinic also has LCSW Teresa Conlan on staff for therapy integration, and the treatment rooms are designed to feel more like a spa than a medical facility. They treat both mood disorders and chronic pain conditions including CRPS, and maintain weekend hours for patient convenience.

“Dr. Abreu and his staff provide a safe, friendly atmosphere. The facility is clean, cozy, and so inviting that it feels like a spa. They address every concern and stay current with all developments in the field.” — Yelp Review

2. Cascade Psychedelic Medicine

Known For: Perfect 5.0 Google rating and one of Oregon’s first clinics to integrate both ketamine and legal psilocybin therapy

Why We Picked Them: Dr. Seth Mehr brings 20 years of ER medicine to psychedelic therapy, combining clinical rigor with a deeply therapeutic approach. The clinic’s integration of ketamine and psilocybin under one roof is rare nationally.

The treatment space at Cascade reflects Dr. Mehr’s holistic philosophy — singing bowls, didgeridoo, and handpan instruments line the treatment room, and he often plays during sessions. This is a clinic for patients who want more than an infusion — they want a transformative therapeutic experience. Sessions book months in advance.

“Dr. Seth has created a safe and inviting atmosphere for healing. The ketamine sessions pulled me out of a challenging depressive period and helped me process past trauma. I highly recommend Cascade Psychedelic Medicine.” — Google Review

3. Rainfall Medicine

Known For: Portland’s Mississippi Ave neighborhood clinic offering the widest range of ketamine delivery methods — IV, IM, sublingual, and KAP

Why We Picked Them: Rainfall Medicine stands out for the breadth of its ketamine options. Whether patients prefer IV infusions, intramuscular injections, or take-home sublingual lozenges, this clinic provides flexible pathways tailored to individual needs.

Located in Portland’s vibrant Mississippi neighborhood, Rainfall Medicine takes a compassionate, integrative approach to ketamine therapy. They also treat substance use disorders with ketamine — a specialization not widely available — and their KAP program offers deeper therapeutic support for patients working through trauma.

“Rainfall Medicine provides a warm, nurturing environment for healing. The team is incredibly supportive and the ketamine therapy has been a turning point in my recovery from depression and anxiety.” — Google Review

4. Achieve Medical

Known For: Part of the SokyaHealth network, offering ketamine therapy alongside comprehensive mental health services in Portland’s Lloyd District

Why We Picked Them: Achieve Medical benefits from SokyaHealth’s broader mental health infrastructure, meaning patients can access psychiatry, therapy, and ketamine treatment within a single integrated system. Their Lloyd District location is one of the most accessible in Portland.

Achieve Medical takes a comprehensive approach — their team works with patients and families to develop personalized treatment plans that extend beyond ketamine sessions. This makes them a good choice for patients who want ongoing psychiatric care alongside their infusion therapy.

“The staff at Achieve Medical are incredibly warm and professional. They took the time to understand my history and created a treatment plan that really works for me.” — Google Review

5. Cornell Pain Clinic

Known For: Dual board certification in pain management and psychiatry — uniquely positioned for patients with co-occurring pain and mood disorders

Why We Picked Them: Dr. Chand’s dual certification in both pain management and psychiatry is rare among ketamine providers. This makes Cornell Pain Clinic especially strong for patients whose chronic pain and depression are intertwined.

Located in Beaverton just west of Portland, Cornell Pain Clinic combines ketamine infusions with regenerative medicine and stem cell therapy. Their pain-first approach makes them the best fit for patients whose primary concern is chronic pain with secondary mood symptoms.

“Dr. Chand is incredibly knowledgeable and takes the time to explain everything. The ketamine infusions have significantly reduced my chronic pain and improved my mood. Highly recommend.” — Google Review

Best Ketamine Clinics in Portland — In Conclusion

Portland’s ketamine therapy scene is uniquely diverse — from traditional anesthesiologist-led infusion clinics to psychedelic-integrated practices offering both ketamine and psilocybin. Portland Ketamine Clinic and Cascade Psychedelic Medicine lead with the highest patient ratings, while Rainfall Medicine offers the most flexible treatment options. For chronic pain patients, Cornell Pain Clinic’s dual-certified approach stands out. We recommend scheduling consultations with two to three clinics to find the right therapeutic fit.

See also: — our ketamine therapy resources.

See also: — our ketamine therapy resources.